Effect of hyperoxia on superoxide anion and hydrogen peroxide production of polymorphonuclear leucocytes and alveolar macrophages

British Journal of Haematology
M Rister, R L Baehner

Abstract

Hyperoxia activates superoxide dismutase (SOD) while inactivating catalase and glutathione peroxidase in polymorphonuclear leucocytes (PMN) and alveolar marcophages (AM) obtained from guinea-pigs exposed to 85% oxygen for 90 h. The influence of these altered enzyme activities on the rate of oxygen consumption and release of superoxide anion (O--2) and hydrogen peroxide (H2O2) was investigated. By 18 h O--2 released from resting PMN increased two-fold and remained elevated through the entire periods of the study, whereas H2O2 release and oxygen consumption at the same time points remained normal. At 66 h PMN phagocytizing opsonized zymosan particles released additional quantities of O--2 and H2O2 and consumed significantly more oxygen compared to the usual increase noted at earlier time points. Although oxygen consumption was almost two-fold higher in AM than PMN, phagocytizing AM released three-fold less O--2 and five-fold less H2O2 than did PMN. Furthermore, AM of animals exposed to hyperoxia no longer exhibited enhanced O--2 production upon exposure to opsonized zymosan. Hydrogen peroxide release progressively decreased at rest but progressively increased during phagocytosis of opsonized zymosan during the 90 h exposure to hy...Continue Reading

References

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Citations

Sep 1, 1982·Blut·M Rister
Feb 8, 1979·European Journal of Pediatrics·M RisterE Gladtke
Jan 1, 1985·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·M Rister, C Wustrow
Jan 1, 1984·Lung·A B FisherM Glass
Jan 1, 1979·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·J N Van Balgooy, E Roberts
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·M W SutherlandH J Forman
Jan 1, 1995·Free Radical Biology & Medicine·J K MurphyH J Forman
Jan 1, 1986·Journal of Free Radicals in Biology & Medicine·G Harrison, H J Forman
Jul 19, 2012·International Journal of Experimental Pathology·Akinori C NagatoSamuel S Valença
Jan 1, 1983·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M Rister, M Vollmering
Aug 1, 1989·Clinical Genetics·N CrostiA Serra

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