Effect of hypertension and cardiac hypertrophy on coronary artery morphology in sudden cardiac death

Circulation
A P BurkeR Virmani

Abstract

Epidemiological studies have shown that hypertension and left ventricular hypertrophy (LVH) increase the risk of sudden cardiac death (SCD) in patients with severe coronary artery disease (CAD). However, autopsy studies comparing the morphological substrates for SCD in normotensives and hypertensives are lacking. Heart weight and coronary plaque morphology were prospectively compared in SCD in 36 hypertensive and 63 normotensive individuals. The frequency of CAD was similar in hypertensives (69%, n = 25) and normotensives (73%, n = 46). In 71 hearts with CAD, acute coronary thrombi were present in 76% of normotensives versus 36% of hypertensives (P = .002), LVH was present in 64% of hypertensives versus 33% of normotensives (P = .01) and in 72% of hypertensives with one-vessel disease versus 17% of normotensives with one-vessel disease (P = .0005), and a healed or acute infarct without acute thrombus was present in 36% of hypertensives versus 9% of normotensives (P = .007). Heart weight was higher in all cases of plaque rupture (519 +/- 109 g) than eroded plaque (381 +/- 92 g, P = .0002). In contrast to hypertensives, normotensive hearts with severe CAD showed a stepwise increase in heart weight with one-, two-, and three-vesse...Continue Reading

References

Jan 1, 1990·Journal of Cardiovascular Pharmacology·J TuomilehtoG Berglund
Nov 14, 1984·The American Journal of Cardiology·J T Bigger
Dec 1, 1984·The American Journal of Cardiology·C A Warnes, W C Roberts
Jan 1, 1983·Cardiology·T RomppanenH Roilas
May 3, 1984·The New England Journal of Medicine·M J Davies, A Thomas
Apr 1, 1993·American Journal of Hypertension·F H Messerli
Jun 23, 1994·The New England Journal of Medicine·N G UrenP G Camici
Aug 1, 1993·Journal of the American College of Cardiology·J M SullivanD M Mirvis

❮ Previous
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Citations

Jan 11, 2007·Herzschrittmachertherapie & Elektrophysiologie·W Motz
Oct 16, 2002·Current Cardiology Reports·Lwin Lwin TinGregory Y H Lip
Jun 12, 2003·Journal of the American College of Cardiology·Allen P BurkeJames E Muller
Oct 11, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Kathryn K CollinsElizabeth D Blume
Oct 24, 2001·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·R VirmaniA Farb
Jan 5, 2002·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·R VirmaniA Farb
May 1, 1997·The New England Journal of Medicine·A P BurkeR Virmani
Aug 12, 2009·European Heart Journal·Enrique GurfinkelRuben Laguens
Jul 10, 2013·Vascular Health and Risk Management·Patience Olayinka AkinwusiAdeleye Abiodun Adeomi
May 23, 2006·AJR. American Journal of Roentgenology·Damini DeyDaniel S Berman
Feb 10, 2012·Journal of Cardiovascular Medicine·Roberto PedrinelliUNKNOWN Gruppo di Studio Ipertensione e Cuore, Societa’ Italiana di Cardiologia
Jul 15, 2003·Current Opinion in Cardiology·Michael PreikBodo-Eckehard Strauer
Sep 24, 1998·Journal of Hypertension·B E StrauerM Kelm
Aug 28, 2012·Pathology, Research and Practice·Mingchang ZhangAllen Burke
Jun 28, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Alfred E Buxton
Jan 27, 2009·International Journal of Cardiology·Masato NishimuraToshihiko Ono
Aug 29, 2007·Current Problems in Cardiology·Mintu Turakhia, Zian H Tseng
Jul 20, 2013·Journal of Forensic Sciences·Mingchang ZhangAllen Burke
Dec 28, 2010·The American Journal of Cardiology·M Teresa SubiranaAntonio Bayés de Luna
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Benjamin T JohnSumeet S Chugh
Mar 6, 1998·American Heart Journal·S P Glasser
Aug 27, 1998·The American Journal of Cardiology·G LemboB Trimarco
Apr 12, 2011·Journal of Cardiothoracic Surgery·Wobbe BoumaMassimo A Mariani
Oct 13, 2009·Journal of the American College of Cardiology·Miranda C A KramerRenu Virmani
Feb 7, 2012·Nitric Oxide : Biology and Chemistry·Christian OpländerChristoph V Suschek
Apr 13, 2013·Atherosclerosis·Alessandro MaurielloSara Casella
Dec 17, 2011·American Heart Journal·Daniel A SteinhausZian H Tseng
Aug 16, 2016·Journal of Electrocardiology·Alfred E BuxtonPeng-Sheng Chen
Feb 27, 2007·Journal of Forensic and Legal Medicine·Hiromasa InoueMasayuki Nata
Aug 18, 2005·Journal of Cardiac Failure·Eric C SteckerJohn H McAnulty
Jan 16, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M-L Kortelainen
Aug 19, 2003·Journal of Hypertension·Joanna K LovettPeter M Rothwell
Jul 11, 2019·JAMA Cardiology·Juha H VähätaloM Juhani Junttila
Feb 25, 2017·Current Hypertension Reports·Marty C TamScott L Hummel
Dec 16, 2018·Journal of Vascular Surgery·Alexander P TaylorSherene Shalhub
Dec 1, 2009·Cardiac Electrophysiology Clinics·Rahul SakhujaRanjan K Thakur
Jun 7, 2021·The American Journal of Forensic Medicine and Pathology·Nora F FnonMahrous A Ibrahim

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