Effect of hyperthyroidism on the biliary release of thiobarbituric acid reactants in the rat

Toxicology Letters
Virginia Fernández, Luis A Videla

Abstract

The influence of daily doses of 0.1 mg 3,3',5-triiodothyronine (T3)/kg for three consecutive days on hepatic lipid peroxidation was assessed by the biliary release of thiobarbituric acid reactants (TBARS) in anesthetized rats. T3 treatment elicited a significant 80% increase in the biliary efflux of TBARS compared to control values, an effect determined by increments in both the TBARS concentration in bile (44%) and in the bile flow (25%). It is concluded that hyperthyroidism-induced oxidative stress stimulates hepatic lipid peroxidation measured in an in situ liver preparation, which significantly correlates with the enhancement in the rate of TBARS production assessed in liver homogenates.

References

Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Jan 1, 1988·Free Radical Research Communications·V FernandezA Boveris
Aug 10, 1987·FEBS Letters·M DubinA O Stoppani
Mar 1, 1982·Biulleten' eksperimental'noĭ biologii i meditsiny·A I MarzoevIu A Vladimirov

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Citations

Jan 1, 1997·Free Radical Biology & Medicine·P TroncosoL A Videla
Jan 16, 1999·Free Radical Biology & Medicine·A GuerreroM López-Torres
Aug 5, 2008·Critical Reviews in Oncology/hematology·Manuela Gago-Dominguez, Jose Esteban Castelao
Nov 13, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·H LinJ Buyse
Jan 6, 2001·Redox Report : Communications in Free Radical Research·L A Videla
Jul 31, 2001·Biochimica Et Biophysica Acta·K Das, G B Chainy
Jan 1, 1997·Nitric Oxide : Biology and Chemistry·V FernándezL A Videla
May 18, 2000·Cell Biochemistry and Function·R WinklerW Wonisch
Nov 22, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Virginia FernándezLuis A Videla

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