PMID: 7017069May 1, 1981Paper

Effect of hypo- and hyperthyroidism on hexokinase in the developing cerebellum of the rat

Journal of Neurochemistry
D I Gutekunst, J E Wilson

Abstract

Total hexokinase levels (units/g tissue) have been measured during postnatal development of the cerebellum in control, hypothyroid, and hyperthyroid rats. In addition. distribution of hexokinase in the developing cerebellum has been observed with an immunofluorescence method. Hypothyroidism delays the normally observed postnatal increase in total hexokinase activity, whereas hyperthyroidism accelerates the increase. In normal animals, hexokinase levels in maturing Purkinje cells pass through a transient increase, with maximal levels at approximately 8 days postnatally followed by rapid decline to relatively low levels by 12 days; hypothyroidism delays this transient increase and subsequent decline, but hyperthyroidism does not appear to affect markedly the timing of this phenomenon. Cerebellar glomeruli are relatively enriched in hexokinase content, as judged by their intense fluorescence. Hypothyroidism delays the development of intensely stained glomeruli. Hyperthyroidism did not appear to cause precocious increase in numbers of glomeruli but may have increased the rate at which the hexokinase was assimilated by newly formed glomeruli. The effects of hypo- and hyperthyroidism on total cerebellar hexokinase levels are interpre...Continue Reading

References

Oct 5, 1979·Science·R M Libbin, P Person
Mar 1, 1974·Journal of Neurochemistry·E W KelloggJ E Wilson
Jul 1, 1972·Archives of Biochemistry and Biophysics·A C Chou, J E Wilson
Feb 1, 1971·The Biochemical Journal·A J Patel, R Balázs

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Citations

Jan 1, 1986·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·O S Jørgensen, P Honegger
Jul 2, 1984·European Journal of Biochemistry·R IentileR M Di Giorgio

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