Effect of hypochlorous acid solution on the eradication and prevention of Pseudomonas aeruginosa infection, serum biochemical variables, and cecum microbiota in rats

Experimental Animals
Kazuo GotoNobuhito Hayashimoto

Abstract

In this study, hypochlorous acid solution, a weak acid, provided as drinking water to rats, was evaluated for its ability to eradicate and prevent Pseudomonas aeruginosa infection, while monitoring its simultaneous effect on serum biochemical variables and microbiota in the rat cecum. The results suggest that the solution could not eliminate the bacteria in the experimentally infected rats; however, the administration of a 10-parts-per-million (ppm) hypochlorous acid solution as drinking water was effective in inhibiting horizontal spread of P. aeruginosa infection among cage mates. Additionally, exposure to hypochlorous solution did not have any effect on serum biochemical variables of the rat including levels of total cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), albumin, total bilirubin, lipase, amylase, urea nitrogen, total protein, calcium (Ca), phosphorus (P), sodium (Na), chlorine (Cl), except for potassium (K) levels. The most frequently isolated bacteria in the rat cecum included species belonging to Bacteroidales, Lactobacillus, Clostridiales, Erysipelotrichaceae, Akkermansia, Coriobacteriales, and Firmicutes. The ratio of the terminal restriction fragment l...Continue Reading

References

Apr 1, 1994·Jikken dobutsu. Experimental animals·N NakamuraT Urano
Sep 13, 2007·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Nadia Silvestry-RodriguezCharles P Gerba
Sep 26, 2012·Biocontrol Science·Tomoko OnoToshio Sato
Apr 29, 2014·Experimental Animals·Motoko TaharaguchiYasuko K Yamada

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Citations

Sep 18, 2015·International Journal of Molecular Sciences·Kazuo AzumaShinsuke Ifuku
Sep 18, 2020·The Journal of Obstetrics and Gynaecology Research·Akira Tsuda, Yasushi Kanaoka
Oct 20, 2018·JCI Insight·Yusuke NakadeTakashi Wada
Dec 18, 2021·Inhalation Toxicology·Bohdan MurashevychPetro Zhminko

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

GeneScan
BioMajest
R

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