PMID: 11333853May 3, 2001Paper

Effect of hypoenergetic feeding and refeeding on muscle and mononuclear cell activities of mitochondrial complexes I--IV in enterally fed rats

The American Journal of Clinical Nutrition
Francoise Briet, K N Jeejeebhoy

Abstract

Previous studies suggested that cell energetics are altered by malnutrition. We hypothesized that nutritional manipulations influence mitochondrial enzyme activities of the electron transport chain in both skeletal muscle and blood mononuclear cells. After a gastrostomy tube was inserted, 44 rats were randomly assigned to 1 of 4 experimental groups: control fed (CF; 364 kJ/d for 7 d), hypoenergetic fed (HF; 92 kJ/d for 7 d), hypoenergetic protein refed (HPR; 92 kJ/d for 7 d and then 129 kJ/d for 1 d), and hypoenergetic glucose refed (HGR; 92 kJ/d for 7 d and then 129 kJ/d for 1 d). The protein and glucose contents of the liquid formulas were different for the HPR and HGR groups. After mitochondria were isolated from the soleus muscle, the activities of complexes I--IV were measured spectrophotometrically. Because of the lack of available tissue, only the activity of complex I was measured in the mononuclear cell extract. The recovery of complex activities in the CF and HF groups was not significantly different in the mitochondrial fraction of the soleus muscle. Compared with that in the CF group, the activities of complexes I--III in the mitochondrial fraction of the soleus muscle and the activity of complex I in mononuclear ce...Continue Reading

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Citations

Sep 24, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Beatriz De-Mateo-SillerasAlberto Miján-de-la-Torre
Oct 26, 2002·The American Journal of Clinical Nutrition·Annie G MadapallimattamKhursheed N Jeejeebhoy
Nov 23, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Megan Boitano
Apr 29, 2004·The American Journal of Clinical Nutrition·Francoise BrietKhursheed N Jeejeebhoy
Dec 14, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Sherif Awad, Dileep N Lobo
Jun 23, 2007·The International Journal of Eating Disorders·Marek BöhmJiri Zeman
Apr 30, 2003·The American Journal of Clinical Nutrition·Francoise BrietKhursheed N Jeejeebhoy
May 21, 2015·The New England Journal of Medicine·Yaseen M ArabiUNKNOWN PermiT Trial Group
Jul 4, 2006·Free Radical Biology & Medicine·Iraklis I PipinosStephen L Dodd

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