Effect of hypolipidemic compounds on lauric acid hydroxylation and phase II enzymes

Biochemical Pharmacology
H ThomasG Siest

Abstract

Treatment of male Fischer 344 rats with various hypolipidemic drugs of different peroxisome proliferating potency (1-benzylimidazole, acetylsalicylic acid, clofibrate, tiadenol) led to an induction of liver lauric acid hydroxylase, whereas probucol, which is not a peroxisome proliferator, did not induce this enzyme. Activity of bilirubin UDP-glucuronosyltransferase was increased by all the compounds tested. The highest increase was observed after treatment with acetylsalicylic acid (2.3-fold). High correlation (r = 0.953) was observed between the activities of lauric acid hydroxylase and the corresponding activities of cytosolic epoxide hydrolase reported previously. The amount of microsomal epoxide hydrolase was not changed by any of the compounds. Whereas clofibrate and tiadenol decreased glutathione S-transferase activity with 1-chloro-2,4-dinitrobenzene as substrate, 1-benzylimidazole and probucol increased this activity. With 4-hydroxynonenal as a substrate qualitatively the same results were obtained with the exception that probucol did not affect the enzyme activity. When glutathione S-transferase activity was measured with cis-stilbene oxide as substrate only the more than five-fold increase after treatment with 1-benzy...Continue Reading

References

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Citations

Mar 1, 1997·General Pharmacology·M OrellanaE Del Villar
Dec 1, 1992·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S I James, J T Ahokas
Oct 1, 1993·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M Hosokawa, T Satoh

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