PMID: 1119580Feb 1, 1975Paper

Effect of hypothalamic lesions on immediate hypersensitivity

The American Journal of Physiology
R C SchiaviM Stein

Abstract

Bilateral electrolytic lesions were placed in the anterior basal hypothalamus of male Hartley-strain guinea pigs. The animals with anterior hypothalamic lesions and a group of sham-operated controls were sensitized 5-10 days postoperatively with ovalbumin in modified Freund's adjuvant. At 18-22 days following sensitization both groups were randomly divided into three subgroups and challenged by intrajugular injections of three different antigen doses. Anaphylactic death and the severity of anaphylaxis in the survivors were recorded. Antibody titers were determined prior to challenge with use of the passive cutaneous anaphylaxis technique. Serial sections of each brain were made for lesion localization. Significant protection against anaphylaxis was found in guina pigs with symmetrical lesions in the anterior hypothalamus. No significant differences in antibody titers were observed between the lesion and sham-operated groups. There were no significant differences in the response of isolated muscle strips from anterior-lesioned and sham-operated guinea pigs to exogenous histamine. Anterior hypothalamic lesions of size and location comparable to those that provided protection against lethal anaphylaxis did not modify the anaphylac...Continue Reading

Citations

Dec 15, 1978·The Journal of Comparative Neurology·C B SaperW M Cowan
Jan 1, 1983·Journal of Neurology·J A Aarli
Nov 1, 1992·The International Journal of Neuroscience·B M MarkovićB D Janković
Apr 1, 1978·Agents and Actions·N Chand, P Eyre
Jan 1, 1983·Scandinavian Journal of Immunology·G RenouxJ M Guillaumin
Jan 1, 1987·Annals of the New York Academy of Sciences·M KatayamaM M Yokoyama
Mar 1, 1988·The International Journal of Neuroscience·G Renoux
Dec 1, 1984·The Journal of Experimental Zoology·B Glick
Jul 1, 1982·Annals of Neurology·W H BrooksW R Markesbery
Oct 1, 1984·Clinics in Dermatology·E Panconesi, N Petrini

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