PMID: 7541108Feb 23, 1995Paper

Effect of hypothyroidism on the expression of cytochrome c and cytochrome c oxidase in heart and muscle during development

Molecular and Cellular Biochemistry
R J StevensD A Hood

Abstract

The effect of thyroid hormone on the expression of mitochondrial proteins was evaluated during development by measuring cytochrome c oxidase (CYTOX) activity and cytochrome c protein and mRNA levels in heart and skeletal muscle of control and hypothyroid rats. Animals were killed at the late fetal, early, and late postnatal stages up to 56 days of age. In heart, CYTOX activity increased 2.3-fold above the fetal level throughout development, most of which occurred prior to 2 days of age. No increase was observed in muscle. CYTOX activity was reduced in hypothyroid animals throughout development in heart compared to controls (by 50% at 56 days), but in muscle no effect of hypothyroidism was observed. In muscle and heart 4- and 1.5-fold increases in cytochrome c above the fetal level were evident by 1 day of age, with further increases to 8.5- and 2.7-fold by 56 days, respectively. The increase in cytochrome c differed from the increase in CYTOX, indicating changes in mitochondrial composition. Hypothyroidism reduced cytochrome c in muscle by 30-35% at 56 days, but had no effect in heart, indicating a muscle type-specific effect of thyroid hormone on cytochrome c protein expression. Cytochrome c mRNA increased rapidly to 4-5 fold ...Continue Reading

References

Sep 1, 1978·The American Journal of Physiology·K M BaldwinR E Lewis
Mar 1, 1979·The American Journal of Physiology·W W Winder
Jan 1, 1979·The American Journal of Physiology·K M BaldwinR E Lewis
Oct 1, 1992·The American Journal of Physiology·D A HoodD Pette
Apr 1, 1991·The American Journal of Physiology·K L Wicks, D A Hood
May 1, 1989·The American Journal of Physiology·D A Hood, J A Simoneau
May 1, 1988·The American Journal of Physiology·D SmithM Sharratt
Aug 1, 1988·FEBS Letters·A Bär, D Pette
Jun 1, 1973·Circulation Research·S F HopkinsD R Wekstein
Apr 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·F W HeggenessV DiStefano
Dec 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·R T DowellE M Hasser
Mar 1, 1994·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·D A HoodM Takahashi
Dec 1, 1982·Biological Trace Element Research·W A Baumgartner, V A Hill

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Citations

Apr 11, 2001·Mutation Research·C D Berdanier, H B Everts
Jan 16, 1999·Free Radical Biology & Medicine·A GuerreroM López-Torres
Feb 6, 2002·Genome Research·Karine ClémentDominique Langin
Nov 8, 2001·Free Radical Research·R GredillaM López-Torres
Oct 3, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Meixin LiuWei Wan
Jul 16, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Kyung Mee KimBong Chul Chung
Feb 19, 2004·American Journal of Physiology. Endocrinology and Metabolism·Treacey E SheehanDavid A Hood
Nov 16, 2006·American Journal of Physiology. Endocrinology and Metabolism·Peter J AdhihettyDavid A Hood
Feb 28, 2009·Journal of Applied Physiology·Matthew P KrauseThomas J Hawke
Feb 9, 2000·American Journal of Physiology. Endocrinology and Metabolism·T MerkulovaM Lucas
Aug 6, 2003·American Journal of Physiology. Endocrinology and Metabolism·Yuxiang WangArend Bonen
Nov 24, 2006·Journal of Applied Physiology·Peter J AdhihettyDavid A Hood
Oct 13, 2000·American Journal of Physiology. Cell Physiology·J Y GreyD A Hood
Apr 13, 2004·American Journal of Physiology. Cell Physiology·Damien FreyssenetDavid A Hood
Feb 1, 2006·Experimental Biology and Medicine·W Thomas Johnson, Holly M Brown-Borg
Jul 17, 1999·The American Journal of Physiology·D FreyssenetD A Hood
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·Marco ColavecchiaDavid A Hood
Mar 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Akio KanazawaKihachiro Horiike
May 8, 2003·American Journal of Physiology. Cell Physiology·Isabella IrrcherDavid A Hood
Mar 3, 2004·Archives of Biochemistry and Biophysics·Suzanne L Iverson, Sten Orrenius

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