PMID: 6168927May 1, 1981Paper

Effect of hypoxia on nucleic acid and protein synthesis in different brain regions

Neurochemical Research
I SerraA M Giuffrida

Abstract

The incorporation of [methyl-3H]thymidine into DNA, of [5-3H]uridine into RNA, and of [1-14C]leucine into proteins of cerebral hemispheres, cerebellum, and brainstem of guinea pigs after 80 hr of hypoxic treatment was measured. Both in vivo (intraventricular administration of labeled precursors) and in vitro (tissue slices incubation) experiments were performed. The labeling of macromolecules extracted from the various subcellular fractions of the above-mentioned brain regions was also determined. After hypoxic treatment the incorporation of the labeled precursors into DNA, RNA, and proteins was impaired to a different extent in the three brain regions and in the various subcellular fractions examined; DNA and RNA labeling in cerebellar mitochondria and protein labeling in microsomes of the three brain regions examined were particularly affected.

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Citations

Apr 1, 1994·Neurochemical Research·G BenziR F Villa
May 1, 1994·Archives of Gerontology and Geriatrics·F PiccoliM Fioravanti
Jul 1, 1994·Neurobiology of Aging·G BenziR F Villa
Aug 1, 1994·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·O PastorisR F Villa
Aug 27, 1993·Annals of the New York Academy of Sciences·R AvolaA M Giuffrida Stella
Oct 1, 1989·Molecular and Chemical Neuropathology·M Alberghina, M Viola
Jul 20, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Daiana Correia LimaDébora Amado
Jan 1, 1983·Birth Defects Original Article Series·M AlberghinaA M Giuffrida Stella
Dec 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F DaganiG Benzi
Jan 1, 1986·Journal of Neuroscience Research·F MarzaticoG Benzi
Jul 1, 1986·Journal of Neurochemistry·S MykitaR Massarelli
Jan 1, 1983·Journal of Neurochemistry·M AlberghinaA M Giuffrida
Dec 1, 1985·Biochemical Pharmacology·P GallettiV Zappia

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