Effect of ibuprofen L-lysinate on bilirubin binding to albumin as measured by saturation index and horseradish peroxidase assays

Journal of Perinatology : Official Journal of the California Perinatal Association
M T C AmbatJ V Aranda

Abstract

To demonstrate, in vitro, the influence of increasing ibuprofen (IBU) concentration on bilirubin-albumin (B-A) binding. The influence of IBU on B-A binding was measured by saturation index and horseradish peroxidase assays. B-A solutions were prepared at B:A ratios of 0.5, 1.0, 1.5 and 2.0 and bilirubin concentrations of 5 and 10 mg per 100 ml. Drug concentrations used were 142.5, 200 and 285 mg l(-1) for IBU and 100 and 200 mg l(-1) for acetyl salicylic acid (ASA). Similar tests were performed on premature newborn sera with bilirubin concentrations of 5 to 10 mg per 100 ml. By the saturation index test, significant displacement of bilirubin from albumin with IBU was demonstrated only on B-A solution with high B:A ratio of 2.0 and IBU concentration of 285 mg l(-1) and was less as compared to ASA. No displacement was observed in the sera of jaundiced neonates. By the horseradish peroxidase assay using B-A solutions, free bilirubin was significantly increased at (1) increasing concentrations of bilirubin in solution and (2) increasing B:A ratios in a solution containing 5 mg per 100 ml of bilirubin. In the sera of jaundiced neonates, significantly higher free bilirubin concentrations were observed when IBU was added to serum with...Continue Reading

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Citations

Feb 18, 2005·European Journal of Pediatrics·Ronald L ThomasJacob V Aranda
Oct 20, 2010·Journal of Perinatal Medicine·Sanjiv B Amin, Nicholas Miravalle
Jan 24, 2014·BioMed Research International·Hesham Abdel-HadyIslam Nour
Oct 12, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·S Noori
Nov 14, 2012·Journal of Neuropathology and Experimental Neurology·Julie A WixeyKathryn M Buller
Aug 6, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Celine ThibautLuc Desfrere
May 29, 2016·Clinics in Perinatology·Sanjiv B Amin
Nov 30, 2014·Seminars in Fetal & Neonatal Medicine·Ichiro MoriokaHajime Nakamura
Apr 28, 2018·The Journal of Physiology·Julie A WixeyS Tracey Bjorkman
May 1, 2008·Expert Review of Clinical Pharmacology·Karel AllegaertGunnar Naulaers
Mar 11, 2010·Pediatric Research·Hanne T SoligardDag Bratlid
Jul 29, 2020·Neurochemical Research·Ferit DurankuşOytun Erbaş
Apr 6, 2012·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Cuneyt TaymanKarel Allegaert

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