Effect of IFN-beta therapy on the frequency and function of CD4(+)CD25(+) regulatory T cells and Foxp3 gene expression in relapsing-remitting multiple sclerosis (RRMS): a preliminary study

Journal of Neuroimmunology
Afshin NamdarMaryam Izad

Abstract

Interferon-beta (IFN-beta) is an immunomodulatory drug of choice to control relapsing-remitting multiple sclerosis (RR-MS), although its function is still unclear. A reduced suppressive function of CD4(+)CD25(+) regulatory T cells (T(reg)) has been shown in RR-MS patients. In this study, to understand the effect of IFN-ss on CD4(+)CD25(+) regulatory T cells, we analyzed the frequency and function of these cells and Foxp3 gene expression before and after treatment. We evaluated the frequency and function of CD4(+)CD25(+)Foxp3(+) regulatory T cells by flow cytometry and co-culture inhibition test respectively and gene expression of Foxp3 by real-time PCR in a longitudinal follow-up study in 18 relapsing-remitting MS patients. Our data revealed that IFN-beta significantly improved frequency and suppressive function of T(reg) cells (P<0.05) without any significant effect on gene expression of Foxp3 after 6 months. The results of the present study indicate that IFN-beta therapy in some of patients with RR-MS may restore function of regulatory T cells and control the unchecked immune cascade activity. Larger longitudinal studies on more MS patients are required to confirm our findings.

References

Aug 1, 1996·The Journal of Experimental Medicine·M AsanoS Sakaguchi
Jul 1, 1997·Journal of the Neurological Sciences·K P WandingerH Kirchner
Jun 1, 1997·The Journal of Clinical Investigation·K GençA T Reder
Mar 11, 1998·Multiple Sclerosis : Clinical and Laboratory Research·S Dhib-Jalbut
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Mar 4, 2003·Nature Immunology·Roli KhattriFred Ramsdell
Apr 7, 2004·The Journal of Experimental Medicine·Vissia VigliettaDavid A Hafler
May 1, 2004·The Journal of Experimental Medicine·Martin A KriegelHanns-Martin Lorenz
Jun 14, 2005·Journal of Neuroscience Research·Jianya HuanArthur A Vandenbark
Oct 19, 2005·Pharmacology & Therapeutics·Adil Javed, Anthony T Reder
Sep 3, 2008·Journal of Clinical Immunology·Cristina Maria CostantinoDavid A Hafler

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Citations

Apr 15, 2011·Journal of Clinical Immunology·Jaime Ramos-CejudoExuperio Diez-Tejedor
Jun 28, 2011·Current Neurology and Neuroscience Reports·Manuel Comabella, Koen Vandenbroeck
Mar 28, 2012·Acta neurologica Belgica·R E Gonsette
Jan 27, 2011·Nature Reviews. Immunology·Daniel J Campbell, Meghan A Koch
Sep 30, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jian Hong, George J Hutton
Mar 4, 2014·Internal Medicine·Ryo Tomioka, Makoto Matsui
Apr 9, 2014·The Journal of Experimental Medicine·Shivani SrivastavaDaniel J Campbell
Aug 17, 2010·International Immunopharmacology·Thomas M Petro
Oct 11, 2016·Mediators of Inflammation·José de Jesús Guerrero-GarcíaDaniel Ortuño-Sahagún
Sep 12, 2015·Brain : a Journal of Neurology·Melanie Piédavent-SalomonManuel A Friese
Feb 7, 2017·The Journal of Clinical Investigation·Vimal RamjeeJonathan A Epstein
May 13, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Sabine LindquistMichael Sailer
Jan 22, 2014·Journal of Internal Medicine·A H Cross, R T Naismith
Apr 10, 2014·Immunological Reviews·Kate S SmigielDaniel J Campbell
Dec 19, 2015·Pharmacogenetics and Genomics·Ekaterina TsarevaOlga Favorova
Feb 28, 2016·Journal of Leukocyte Biology·Ilenia PacellaSilvia Piconese
Apr 18, 2020·Journal of Translational Medicine·Marco ChiariniUNKNOWN SURROGATE Study Group
Aug 6, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shivani SrivastavaDaniel J Campbell
Sep 14, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Duncheng WangMark D Mannie
Jan 21, 2020·Frontiers in Immunology·Manolo SambucciGiovanna Borsellino
Jul 16, 2010·Cytokine & Growth Factor Reviews·Fabrizio MatteiDavid F Tough

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