PMID: 8589273May 1, 1995Paper

Effect of IFN-gamma administration in virgin and pregnant mice: distribution of lymphoid and myeloid cells in the spleen

European Cytokine Network
I Athanassakis, S Vassiliadis

Abstract

Administration of Interferon-gamma (IFN gamma) is used in the therapeutic approach for mainly cancer treatment and viral infections in vivo. Recently we observed some important pathologic dysfunctions caused by IFN-gamma administration to pregnant mice. This treatment affected not only the growth and development of the feto-placental unit, but also, among other hematologic disorders, caused splenomegaly to the mother. In an effort to explain the observed hypersplenism, we have analysed the behaviour of macrophages, B and T lymphocytes in the spleen of virgin and pregnant mice after intraperitoneal administration of low IFN-gamma doses. Although the percentage of myeloid Mac-1 and F4/80 positive cells in spleen cell suspensions of virgin and pregnant mice do not change with the IFN-gamma treatment, immunoperoxidase staining of frozen spleen sections shows that in pregnant mice the monocytic cells accumulate at the central white pulp area of the organ, whereas in non-pregnant mice these cells are mainly found at the peripheral red pulp area. In contrast, the same treatment was shown to increase the numbers of Ly5 positive B cells in both virgin and pregnant mice, whereas B cells were found to form clusters only in the case of pre...Continue Reading

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