Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B.

Annals of Dermatology
Seok-Yong AhnWon-Soo Lee

Abstract

Insulin-like growth factor-I (IGF-I) shares a high degree of structural and functional homology with insulin and is a potent mitogen supporting cell growth and survival in many kinds of the tissues and cells. It also plays a role in some differentiation and anti-apoptotic functions. In previous reports, it has been shown that IGF-I stimulates hair follicle (HF) growth, maintains the anagen stage, and postpones the catagen stage. The exact mechanism of the effect of IGF-I on HF growth is not yet established. Therefore, we investigated the relationships between IGF-I and various other factors (i.e. apoptosis related molecules, pro-inflammatory cytokines, other growth factors, etc.) in the control of HF growth. The effect of IGF-I on human hair growth was measured using an organ culture model of human HFs and compared with a control group that did not receive IGF-I. We also measured mRNA expression of factors related to hair growth and apoptosis (which was determined by reverse transcription polymerase chain reaction (RT-PCR). RT-PCR was done on days 2, 4, 6, and 8 of organ culture. In organ cultured human hair follicles, IGF-I had a positive effect on the rate of linear hair growth. IGF-I maintained the anagen phase. IGF-I increa...Continue Reading

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Citations

Nov 6, 2012·Archives of Dermatological Research·Hassnaa MahmoudiRegina C Betz
Jul 17, 2015·International Journal of Trichology·Gkini Maria-AngelikiKouskoukis Konstantinos
Oct 27, 2017·International Journal of Molecular Sciences·Bozena HosnedlovaRene Kizek
Feb 6, 2016·Annals of Dermatology·Semchin MunkhbayarOhsang Kwon
Feb 27, 2016·F1000Research·Bruno A Bernard
Jan 31, 2019·Animals : an Open Access Journal From MDPI·Irene PazzagliaCarlo Renieri
Mar 3, 2019·Experimental Biology and Medicine·Xinping LiMingsheng Zhang
Sep 16, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Aditya K Gupta, Jessie Carviel
Sep 20, 2018·Nature Communications·Jérémy ChéretRalf Paus
Jun 19, 2020·Animals : an Open Access Journal From MDPI·Xiaoyang LvJinyu Wang
Feb 26, 2019·Animal Biotechnology·Mei JinJing'ai Piao
Oct 1, 2019·Annals of Dermatology·Xing-Hai JinWon-Soo Lee

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Methods Mentioned

BETA
PCR

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )

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