Effect of imatinib on growth of experimental endometriosis in rats

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Caglar YildizAli Cetin

Abstract

Currently, medical and surgical treatment options for endometriosis are limited due to suboptimal efficacy, and also safety and tolerance issues. Long-term use of gonadotrophin-releasing hormone analogs, androgenes, and the danazol, which are widely used drugs for endometriosis, is usually not possible due to their suboptimal safety and tolerance profile. The lack of an effective, tolerable and safe treatment option for endometriosis makes animal models of experimental endometriosis necessary to study candidate drugs. The aim of this study was to investigate the efficacy of imatinib on the experimental endometriosis in a rat model. Endometriosis was induced by autotransplantation of uterine tissue into the peritoneal cavity. Twenty-four rats, which had visually confirmed endometriotic implants on subsequent laparotomy, were randomized into three groups to receive imatinib (25mg/kg/day, p.o.), anastrozole (0.004 mg/day, p.o.), or normal saline (0.1 mL, i.p.) for 14 days. After removal of endometriotic tissue and H & E staining, endometriosis score was determined according to a semiquantitative histological classification. Also, immunostaining with primary antibodies including VEGF, CD117, and Bax were used for immunohistochemica...Continue Reading

References

Aug 4, 1998·Human Reproduction·J DonnezM Nisolle
Aug 15, 2003·Seminars in Reproductive Medicine·Thomas M D'HoogheChristel Meuleman
Aug 21, 2003·Human Reproduction Update·Paolo VercelliniPier Giorgio Crosignani
Nov 13, 2004·The New England Journal of Medicine·Tara SeshadriGrant A McArthur
Apr 6, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Inger B CarlssonOuti Hovatta
Jun 1, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Eric E NilssonMichael K Skinner
Nov 14, 2006·Journal of Minimally Invasive Gynecology·Anthony A Luciano
Jun 23, 2007·Human Reproduction Update·S SimoensT D'Hooghe
Mar 7, 2008·The New England Journal of Medicine·Constantinos ChristopoulosEvangelos Rotas
Nov 8, 2008·Fertility and Sterility·Jani R JensenRajeshwar R Tekmal
Sep 29, 2009·Nature Medicine·Stefania GonfloniGianni Cesareni
Dec 17, 2009·Women's Health·Tasuku Harada, Fuminori Taniguchi
Dec 2, 2011·Leukemia Research·Charles Chuah
Aug 17, 2012·Reproductive Sciences·Hatice OzerMehmet Ilkay Kosar
Jan 30, 2013·Expert Opinion on Pharmacotherapy·Isabelle StreuliCharles Chapron
Aug 21, 2013·Recent Patents on Inflammation & Allergy Drug Discovery·Gholamreza Azizi, Abbas Mirshafiey
Feb 6, 2014·American Journal of Obstetrics and Gynecology·Yifeng WangFenghua Liu
Jun 26, 2014·Chemotherapy Research and Practice·Nida Iqbal, Naveed Iqbal
Jun 27, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Luciano GibranSergio Podgaec
Jul 1, 2014·Current Opinion in Obstetrics & Gynecology·Lieven Platteeuw, Thomas D'Hooghe
Jan 27, 2015·Pulmonary Circulation·Samar FarhaKewal Asosingh
Feb 3, 2015·Recent Patents on Endocrine, Metabolic & Immune Drug Discovery·Donald Poirier
Apr 29, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Angela Cioffi, Robert G Maki
May 6, 2015·Expert Review of Hematology·Benedito A CarneiroFrancis J Giles
May 16, 2015·Trends in Pharmacological Sciences·Peng WuMads H Clausen

❮ Previous
Next ❯

Citations

Apr 11, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Guanghui ZhuYing Cao
Dec 16, 2019·Journal of Materials Science. Materials in Medicine·Safieh BoroumandMohammad Salehi
Jul 28, 2020·Reproductive Biomedicine Online·Dingmin YanSun-Wei Guo
Aug 20, 2020·The Journal of Clinical Endocrinology and Metabolism·Dingmin YanSun-Wei Guo
Dec 18, 2018·Pharmacology & Therapeutics·Asuncion Martinez-AntonPascal Chanez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
H G PalaA Yavasoglu
The Australian & New Zealand Journal of Obstetrics & Gynaecology
Ismail Mete ItilNiyazi Askar
European Journal of Obstetrics, Gynecology, and Reproductive Biology
Mesut OktemPolat Dursun
© 2022 Meta ULC. All rights reserved