PMID: 3767795Jun 1, 1986Paper

Effect of imidocarb dipropionate prophylaxis on the infectivity and immunogenicity of a Babesia bovis vaccine in cattle

Australian Veterinary Journal
A de VosW McGregor

Abstract

Imidocarb dipropionate (IDP), a potent prophylactic drug against Babesia bovis infections in cattle, was tested for its effect on the infectivity and immunogenicity of a live B. bovis vaccine marketed in Australia. At the recommended prophylactic dose rate of 3 mg/kg, IDP suppressed infectivity of the vaccine for at least 6 weeks. The vaccine infected all cattle inoculated either 8 weeks after treatment with 3 mg/kg, or 4 weeks after treatment with the recommended therapeutic dose of 1.2 mg/kg. These infections were, however, partially suppressed and the level of immunity to a subsequent heterologous virulent challenge was reduced. Cattle that failed to become infected after vaccination were fully susceptible to the challenge. It is concluded that where B. bovis vaccination is contemplated, prophylactic use of IDP should be avoided.

References

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Citations

Feb 1, 1987·International Journal for Parasitology·A D Irvin
Jun 1, 1992·Veterinary Parasitology·R E BockR J Dalgliesh
Mar 1, 1995·Veterinary Parasitology·E Pipano
Nov 5, 2013·Experimental Parasitology·Monica L MazuzVarda Shkap
Jul 30, 2014·Parasitology·Monica Florin-ChristensenLeonhard Schnittger
Feb 15, 2011·Molecular and Biochemical Parasitology·Martin SimuunzaWilliam Weir
Jun 9, 2005·Parasitology·R BockW Jorgensen
May 9, 2008·Journal of Bioinformatics and Computational Biology·Zoi I LitouStavros J Hamodrakas
Dec 3, 2020·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Jerbeson Hoffmann da SilvaCarlos Bondan

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