Effect of immobilization stress on brain polyamine levels in spontaneously hypertensive and Wistar-Kyoto rats

Brain Research Bulletin
Hyung Seok SohnSeong Ryong Lee

Abstract

The present study aimed to compare the basal brain polyamine levels and stress-induced brain polyamine level changes in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. For immobilization stress, both strains underwent acute (3 h per day immobilization for 2 days), chronic (3 h per day immobilization for 15 consecutive days), or no immobilization stress (control group). Basal putrescine (PU) levels in frontal cortex and hippocampus of SHR (11.03 +/- 0.81 and 11.36 +/- 0.33 nmol/g tissue, respectively) were significantly higher than WKY rats (6.90 +/- 1.44 and 7.82 +/- 0.71 nmol/g tissue, respectively). However, there were no strain differences in basal spermidine and spermine levels between the two. After acute stress, the PU levels in frontal cortex and hippocampus (15.99 +/- 0.45 and 14.10 +/- 0.95 nmol/g tissue, respectively) were significantly increased in SHR as compared to the non-stressed SHR (11.03 +/- 0.81 and 11.36 +/- 0.33 nmol/g tissue, respectively). In WKY rats, the PU level was significantly increased by acute stress in frontal cortex (11.68 +/- 1.12 nmol/g tissue) as compared to the non-stressed WKY (6.90 +/- 1.44 nmol/g tissue). After chronic stress, the PU levels in frontal cortex and hippoca...Continue Reading

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Citations

Mar 5, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gary Gang ChenGustavo Turecki
Sep 22, 2009·Progress in Neurobiology·Carl ErnstGustavo Turecki
Jan 20, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Timothy A KlempanGustavo Turecki
Mar 28, 2008·The European Journal of Neuroscience·Meng-Yang ZhuGregory Ordway
Sep 21, 2005·Autonomic Neuroscience : Basic & Clinical·Ljubica GavrilovicSladjana Dronjak
Sep 5, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Alan Alexander González IbarraKazimierz Wrobel

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