Effect of immunosuppression on the development of experimental hematogenous Candida endophthalmitis.

Infection and Immunity
D K HendersonJ E Edwards

Abstract

The induction of neutropenia and immunosuppression by the administration of nitrogen mustard (HN2) decreased the frequency and altered the morphology of clinically detectable hematogenous Candida endophthalmitis in the rabbit model of disseminated candidiasis. Whereas 95% of eyes in rabbits infected with Candida albicans without pretreatment with HN2 developed typical lesions of hematogenous Candida endophthalmitis, only 6.2% of eyes in rabbits that had been given 3.0 mg of HN2 per kg developed clinically detectable endophthalmitis. Lesions that developed in the severely immunocompromised and neutropenic rabbits were small and atypical in appearance. From these data, we conclude that ophthalmoscopic examination may not be a sensitive diagnostic modality for disseminated candidiasis in severely immunocompromised, neutropenic patients.

References

Jun 1, 1975·The Journal of Infectious Diseases·J E EdwardsL B Guze
Feb 1, 1978·The Journal of Infectious Diseases·J Z Montgomerie, J E Edwards
Oct 21, 1972·Lancet·S C SchimpffJ B Block
Mar 30, 1972·The New England Journal of Medicine·L S FishmanR Hecht

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Citations

Jan 1, 1995·Mycoses·U SchulerG Ehninger
Oct 12, 2000·Clinical Microbiology Reviews·S A KlotzS I Butrus

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