Effect of Immunosuppressive Therapies for the Treatment of Inflammatory Bowel Disease on Response to Routine Vaccinations: A Meta-Analysis

Digestive Diseases and Sciences
Douglas L NguyenMatthew L Bechtold

Abstract

Several studies have evaluated the effect of immunosuppressive therapy for the treatment of inflammatory bowel disease (IBD) on response to routine vaccinations. The overall effect of specific classes of medications (i.e., immunomodulator vs. biologics) on vaccine response remains undefined. The aim of this study was to determine the effect of each class of immunosuppressive therapy in IBD patients on response to routine vaccinations. A comprehensive search of PubMed/MEDLINE, Scopus, CINAHL, and Cochrane databases was performed (December 2014). All studies on adults comparing vaccine response among IBD patients on immunosuppression with non-immunosuppressed patients were included. Meta-analysis was performed using the Mantel-Haenszel (fixed effects) model with odds ratio (OR) to assess for adequate vaccine response. In the pooled analysis of nine studies (N = 1474), we found that there was nearly a 60 % lower chance of achieving adequate seroprotection in the group that received immunosuppressive therapy compared to the group that was not on any immunosuppressive therapies (OR 0.41 95 % CI 0.30, 0.55, p < 0.001). Specifically, we also demonstrated that patients on immunomodulator monotherapy had a twofold higher probability of ...Continue Reading

References

May 2, 2001·American Journal of Preventive Medicine·L E Barker, E T Luman
Oct 9, 2004·Inflammatory Bowel Diseases·Bruce E SandsWalter Orenstein
Jul 5, 2006·The American Journal of Gastroenterology·Gil Y MelmedEric A Vasiliauskas
Sep 4, 2007·The American Journal of Gastroenterology·Omid A ShayeTram T Tran
Dec 7, 2007·Gastroenterology·Susan M HutflessLisa J Herrinton
Feb 26, 2008·Gastroenterology·Murat TorunerLaurence J Egan
May 2, 2009·Inflammatory Bowel Diseases·Ying LuAthos Bousvaros
Sep 17, 2009·The American Journal of Gastroenterology·Gil Y MelmedEric A Vasiliauskas
Jan 28, 2010·The American Journal of Gastroenterology·Sharmeel K WasanFrancis A Farraye
Mar 26, 2011·Inflammatory Bowel Diseases·Iris DotanLloyd Mayer
Dec 8, 2011·Digestive Diseases and Sciences·Mustafa Erhan AltunözAyşe Oya Kurdaş Ovünç
Mar 22, 2013·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Amanda C CohnUNKNOWN Centers for Disease Control and Prevention (CDC)
Mar 30, 2013·World Journal of Gastroenterology : WJG·Pilar López-SerranoMaria Dolores Sánchez-Tembleque
Oct 23, 2013·Journal of Crohn's & Colitis·Chang Kyun LeeUNKNOWN Korean Association for the Study of Intestinal Diseases (KASID) Study
Aug 28, 2014·Journal of Gastroenterology and Hepatology·Yolima Cossio-GilFrancesc Casellas-Jordà

❮ Previous
Next ❯

Citations

Jan 11, 2017·The American Journal of Gastroenterology·Francis A FarrayeSunanda V Kane
Mar 7, 2017·The Journal of Infection·Giovanni MazzolaAmbrogio Orlando
Jun 22, 2018·Future Microbiology·James A ChurchAndrew J Prendergast
Feb 3, 2016·The Journal of Rheumatology·Nico M Wulffraat, Marloes W Heijstek
Nov 23, 2018·Journal of Cutaneous Medicine and Surgery·Kim A PappJohn Wade
Jun 18, 2019·The American Journal of Gastroenterology·Laure F PittetUNKNOWN Swiss Inflammatory Bowel Disease Cohort Study Group
Feb 8, 2020·The Pediatric Infectious Disease Journal·Łukasz DembińskiAndrzej Radzikowski
Jun 20, 2020·Journal of Pediatric Gastroenterology and Nutrition·Łukasz DembińskiAleksandra Banaszkiewicz
Nov 7, 2019·Current Treatment Options in Gastroenterology·Anthony J ChoiDana J Lukin
Dec 2, 2020·Zeitschrift für Gastroenterologie·Torsten KucharzikUNKNOWN Collaborators:
Mar 10, 2021·Infectious Diseases and Therapy·Elda RighiEvelina Tacconelli
Apr 3, 2021·Human Vaccines & Immunotherapeutics·Łukasz DembińskiAleksandra Banaszkiewicz
Oct 31, 2020·Gastroenterology Clinics of North America·Jason Harper
Jun 13, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Fabio Salvatore MacalusoMassimo Galli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.