Effect of implanted insulin pumps on fluorescein transcapillary escape time in type 1 diabetes mellitus.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
C E AhlforsA T Cheung

Abstract

To determine whether significant increases in fluorescein transcapillary escape time (FTET) would occur after treatment of patients with type 1 diabetes with insulin delivered intraperitoneally by a surgically implanted pump. Nine patients with type 1 diabetes who were otherwise healthy and had received surgically implanted insulin pumps on a study protocol were recruited to have three measurements of FTET and glycosylated hemoglobin during an 18-month period. Serum fluorescein-albumin binding was measured at the time of the final test. Control FTETs were measured in 46 patients with type 1 diabetes who did not have insulin pumps and in 15 adults without diabetes. In the implanted insulin pump group, 50% of the FTETs were below normal, but no significant longitudinal change in FTETs was noted in eight of the nine study patients. The mean FTETs in the implanted insulin pump group were significantly higher than those of the control patients with diabetes but without insulin pumps (mean, 88 versus 62 seconds; P<0.05) but significantly lower than those of the control subjects without diabetes (88 versus 163 seconds; P<0.001). Four of the nine patients with implanted insulin pumps had normal FTETs on all three studies. This subgroup...Continue Reading

References

Nov 18, 1982·The New England Journal of Medicine·A BollingerW Siegenthaler
Apr 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C E AhlforsK L Cox
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert

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