Effect of In-Utero Antibiotic Exposure on Childhood Outcomes: Methods and Baseline Data of the Fetal Antibiotic EXposure (FAX) Cohort Study

JMIR Research Protocols
Corinna KoebnickDarios Getahun

Abstract

The widespread use of antepartum and intrapartum antibiotics has raised concerns about the possible disruption of the child's gut microbiota and effects on the maturation from the infant to the adult microbiome. The Fetal Antibiotic EXposure (FAX) study provides a cohort to examine the association between in-utero exposure to antibiotics and adverse childhood outcomes including body weight, atopic diseases, and autism spectrum disorders and to investigate the role of other potential factors mitigating or moderating the risk for adverse outcomes. The aim of this paper was to describe the methods, cohort characteristics, and retention of infants included in the study cohort. For this retrospective cohort study, we included children born in Kaiser Permanente Southern California (KPSC) hospitals between January 1, 2007, and December 31, 2015, within 22 to 44 completed weeks of gestation with KPSC insurance coverage during the first year of life. Follow-up data collection was performed through electronic medical records. The study cohort was comprised 223,431 children of which 65.7% (146,720/223,431) were exposed to antibiotics in-utero: 19.0% (42,511/223,431) were exposed during the antepartum period, 30.0% (66,896/223,431) during ...Continue Reading

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Citations

Jul 19, 2020·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Marcelo CardettiAugusto Sola
Jan 26, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Corinna KoebnickStephanie J Schrag

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