Effect of in vitro cyclosporin. A treatment on human natural and antibody-dependent cell-mediated cytotoxicity

Transplantation
C Shao-HsienP Lydyard

Abstract

Concentrations of 0.1 to 10.0 micrograms of cyclosporin A (Cy A) per ml do not directly inhibit the lysis of 51Cr-labeled K562 target cells by human peripheral blood natural killer (NK) cells nor of antibody-coated chicken red blood cells by antibody-dependent cellular cytotoxicity (ADCC) effector cells. Pretreatment of effector cells with Cy A for 18 hr still failed to affect NK or ADCC effector function. However, induction of NK cell activity by overnight pretreatment of effector cells by polyinosinate-polycytidylate (PolyIC) is inhibited by as little as 1 micrograms of Cy A per ml. The mechanism of inhibition may involve a direct effect of Cy A on "induced" or "activated" NK cells or inhibition of the release of Poly IC-induced interferon from lymphocytes.

Citations

Oct 1, 1984·Agents and Actions·A W ThomsonJ G Simpson
Aug 18, 1995·Journal of Immunological Methods·M Okano, D T Purtilo
May 1, 1985·Journal of the American Academy of Dermatology·A M MaddoxR E Jordan
Nov 2, 1999·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M BroyerC Loirat
Mar 18, 2011·Journal of Innate Immunity·Jean Villard
Oct 23, 2010·PloS One·Olivier MorteauChristopher A O'Callaghan
Aug 20, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Karine HadayaJean Villard
Sep 3, 2008·Cellular Immunology·Arun T Pores-FernandoAdam Zweifach
Oct 1, 1992·Clinical Immunology and Immunopathology·H LuoJ Wu

Related Concepts

Related Feeds

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex, associated with a generally dismal prognosis owing to its aggressive behavior. Here are the latest discoveries pertaining to this disease.