PMID: 3756207Oct 1, 1986Paper

Effect of in vivo gamma-irradiation on the binding of wheat germ agglutinin on lymphocyte plasma membranes

Biochimica Et Biophysica Acta
P MoullierJ Hoebeke

Abstract

Using quantitative fluorimetry with fluoresceinated wheat germ agglutinin, we have been able to investigate in vivo gamma radiation-induced damage at the outer membrane level of rat splenic lymphocytes, namely damage to the glucosidic moieties of membrane glycoproteins and glycolipids. This paper demonstrates that below an irradiation level of 1 gray (Gy), removal of sialic acid is the major feature leading to new exposed specific binding sites for wheat germ agglutinin, since this lectin is specific for sialic acid and N-acetyl-D-glucosamine. Our studies also suggest that above 1 Gy of irradiation more internal damage occurs, since we observed a striking decrease in wheat germ agglutinin binding sites.

References

Feb 12, 1976·Nature·G J KötelesL Varga
Jan 1, 1984·Radiation and Environmental Biophysics·T KubasovaG J Köteles
Jan 1, 1980·Psychophysiology·A J FridlundD A Pritchard
Jan 29, 1982·Biochemical and Biophysical Research Communications·J BanchereauJ Drouet

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Citations

Jan 1, 1989·Radiation and Environmental Biophysics·I BallaW Schmahl
Jan 1, 1993·Radiation and Environmental Biophysics·M C Nievergelt-EgidoW Schmahl
Dec 10, 1999·Micron : the International Research and Review Journal for Microscopy·Z Somosy

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