PMID: 9182409Mar 1, 1997Paper

Effect of inactivated Ebola virus on colony forming activity of human hematopoietic stem cells

Voprosy virusologii
A A ChepurnovI V Chernukhin

Abstract

The effect of Ebola virus antigen on the growth of hemopoietic precursors was studied. Incubation of mononuclear cells with the viral antigen led to a dose-dependent decrease of erythroid colony formation but did not alter the growth of the granulocyto-macrophagal precursors. Hence, Ebola virus antigen is capable of directly affecting the hemopoietic activity of precursors in man by inhibiting the growth of erythroid colonies.

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