PMID: 15385863Sep 24, 2004Paper

Effect of inactivity and undernutrition after acute ischemic stroke in a rat hindlimb muscle model

Nursing Research
Myoung-Ae ChoeMargaret Heitkemper

Abstract

Stroke patients experience functional changes resulting from muscle atrophy related to disuse, lack or limited neuronal stimulation, and undernutrition. Acute ischemic stroke is assumed to induce muscle atrophy. However, there is little information regarding muscle changes after acute stroke. The purpose of this study was to examine the effect of inactivity and undernutrition after acute stroke on mass, myofibrillar protein content, and Types I and II fiber cross-sectional areas of rat hindlimb muscles. Adult male Sprague-Dawley rats (body weight, 240-270 g) were randomly assigned to one of three groups: a stroke group (n = 7) that had occlusion of the right middle cerebral artery, a control group (n = 7) that underwent a sham right middle cerebral artery procedure, and an undernourished group (n = 9) that was pair-fed to match the intake of stroke rats. Food and water intake as well as body weight were measured daily. The rats were anesthetized 7 days after occlusion or sham occlusion, after which the soleus (Type I), plantaris (Type II), and gastrocnemius (Type II) muscles were dissected from both the affected and unaffected sides. The brain was sectioned to identify cerebral infarction in the stroke group. Body weight, food ...Continue Reading

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Citations

Dec 1, 2007·Journal of Neuroengineering and Rehabilitation·Cheng-Chi Tsao, Mehdi M Mirbagheri
Apr 13, 2011·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hisashi TakahashiTomoshige Koga
Feb 9, 2012·Journal of Korean Academy of Nursing·Myoung Ae ChoeSonghee Jeon
Sep 8, 2010·Journal of Korean Academy of Nursing·Yongbum Kim, Myoung-Ae Choe
Jul 3, 2009·Journal of Korean Academy of Nursing·Jin Il Kim, Myoung-Ae Choe
Mar 24, 2006·Biological Research for Nursing·Myoung-Ae ChoeMargaret Heitkemper
May 9, 2015·Stroke; a Journal of Cerebral Circulation·Marine Maud DesgeorgesDamien Gilles Freyssenet
Oct 30, 2014·Stroke; a Journal of Cerebral Circulation·Jochen SpringerWolfram Doehner
Nov 30, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chandan K SenCameron Rink
Jan 5, 2011·Biological Research for Nursing·Myoung-Ae ChoeMargaret Heitkemper
Dec 5, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R T R MeloI R S C Maldonado
Dec 23, 2019·Translational Stroke Research·Michael J HaleyCatherine B Lawrence
Sep 22, 2012·Biological Research for Nursing·Jee Yoon Kim
Apr 8, 2021·Neurorehabilitation and Neural Repair·Matthew W McDonaldDale Corbett

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