Effect of incorporating antifungals on the water sorption and solubility of interim resilient liners for denture base relining

The Journal of Prosthetic Dentistry
Jozely F M LimaKarin H Neppelenbroek

Abstract

Incorporating antifungals into interim denture resilient liners has been proposed to prolong their clinical longevity and to treat denture stomatitis. However, information is lacking on the effect of this addition on water sorption and solubility. The purpose of this in vitro study was to evaluate the addition of minimum inhibitory concentrations (MICs) of antifungals for Candida albicans biofilm on the water sorption (WS) and solubility of interim denture resilient liners. Disk-shaped specimens (n=10; 50×0.5 mm) of tissue conditioner (Softone) and resilient liner (Trusoft) were created either without (control) or with the incorporation of 1 of the 3 following drugs at MICs (g of drug per g of resilient material powder): nystatin (Ny, 0.032g/g), chlorhexidine diacetate (Chx, 0.064g/g), and ketoconazole (Ke, 0.128g/g). Specimens were dried; immersed in water for 24 hours and 7 or 14 days; weighed, dried, and weighed again. Data (μg/mm(3)) were analyzed by 3-way ANOVA followed by the Tukey-Kramer honest significant differences test (α=.05). At the 14-day interval, only the addition of Chx (483.0 ±61.0 μg/mm(3)) increased the WS of the tissue conditioner compared with the control group (244.0 ±42.0 μg/mm(3); P<.001). For all perio...Continue Reading

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Citations

Nov 5, 2016·Journal of Applied Oral Science : Revista FOB·Karin Hermana Neppelenbroek
May 12, 2017·Brazilian Dental Journal·Mírian Galvão BuenoKarin Hermana Neppelenbroek
Jul 27, 2018·Acta Odontologica Scandinavica·Juan Aitken-SaavedraAlfredo Molina-Berríos
Mar 4, 2021·Journal of Applied Oral Science : Revista FOB·Adelaida SÁnchez-AliagaVanessa Migliorini Urban

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