Effect of increased gastric mucosal histamine on alcohol-induced gastric damage in rats

Digestive Diseases and Sciences
D AuresM I Grossman


The aim of this study was to determine whether the cytoprotective effect of prostaglandin might be mediated, at least in part, by inhibition of intramucosal histamine release. Intragastric instillation of increasing concentrations of ethanol in 150 mM HCl resulted in increasing lesion scores and increasing histamine release into the gastric content. Pretreatment with 16,16-dimethyl prostaglandin E2 significantly reduced both lesion scores and gastric histamine output. The intragastric instillation of histamine with tracer [14C]histamine either with or after 50% ethanol resulted in significant gastric tissue uptake of histamine and increased acid secretion. However this had no effect on lesion score, protein output or the protective effect of prostaglandin pretreatment. We conclude that the cytoprotective effect of 16,16-dimethyl prostaglandin E2 in the rat is independent of intramucosal histamine release.


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Nov 10, 2017·Alcoholism, Clinical and Experimental Research·Julian E DilleyJanice C Froehlich
Jun 1, 1985·Scandinavian Journal of Gastroenterology·S J Konturek
May 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·J C del ValleJ E Felíu
Sep 28, 2020·Experimental Brain Research·Renata Ferreira Sgobbi, Manoel Jorge Nobre

Related Concepts

Gastric Juice
Structure of Pyloric Gland
Histamine Release
Hydrogen Chloride
Prostaglandins E
Gene Products, Protein
August Rats

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