PMID: 6402269Jan 24, 1983Paper

Effect of increasing carbon chain length on organic acid transport by the choroid plexus: a potential factor in Reye's syndrome

Brain Research
C S KimC R Roe

Abstract

Transport of the anionic herbicide 2,4-dichlorophenoxyacetic acid by choroid plexus is inhibited significantly by several short and medium chain acids. For both monocarboxylic and dicarboxylic homologs, inhibition clearly increases with chain length. It appears that organic acid compounds of longer chain length, higher brain uptake index, and highest inhibition of choroid plexus transport would be the ones producing the most significant increases in intracranial pressure in metabolic encephalopathy such as Reye's syndrome.

References

Sep 1, 1978·Neurology·D A Trauner, P R Huttenlocher
Mar 15, 1980·Toxicology and Applied Pharmacology·C S KimJ D Mann
Nov 1, 1956·The Journal of Clinical Investigation·D R DAHLF E SAMSON

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Citations

Jul 19, 1991·Brain Research·C S Kim, C R Roe
Feb 11, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Simon Edward Olpin
Sep 17, 1984·Brain Research·C S KimC R Roe
Jun 15, 2010·Life Sciences·Patrícia Fernanda SchuckMoacir Wajner
Jan 1, 1995·Critical Reviews in Clinical Laboratory Sciences·D C Lehotay, J T Clarke
Nov 8, 2007·Free Radical Research·Patrícia F SchuckMoacir Wajner

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