PMID: 847231Feb 1, 1977Paper

Effect of indomethacin on atropine-resistant transmission in rabbit and monkey urinary bladder: evidence for involvement of prostaglandins in transmission

A Johns, D M Paton


The effects of 2.9 x 10(-5)M atropine and 2.8 x 10(-6)M indomethacin on responses of rabbit and monkey detrusor muscle to transmural stimulation were investigated. Response to transmural stimulation were partially inhibited by atropine. Indomethacin caused further inhibition in the presence of atropine, but did not alter responses to acetylcholine. Prostaglandins E2 and F2alpha contracted rabbit and monkey detrusor. It is suggested that prostaglandins are liberated during stimulation of excitatory nerves to the rabbit and monkey detrusor, and contribute to the resultant contractile response.


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Oct 1, 1970·The Journal of Physiology·N Ambache, M A Zar
Nov 1, 1968·British Journal of Pharmacology·A BennettG B Scholes
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