PMID: 696271Aug 1, 1978Paper

Effect of indomethacin on collagen metabolism of rat fracture callus in vitro

Acta Orthopaedica Scandinavica
J RoJ Sander

Abstract

The collagen metabolism of callus tissue from closed, non-immobilized rat femoral fractures was studied in vitro after in vivo treatment with indomethacin 2 mg/kg/day for 6, 9 and 12 days after fracture. Total hydroxyproline synthesis and incorporation of hydroxyproline into collagen were found to be significantly increased after indomethacin treatment, whereas no significant difference was found regarding collagen resorption. The results suggest that the recently demonstrated inhibition of fracture healing by indomethacin is not brought about by an inhibition of collagen synthesis.

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Citations

Jan 1, 1986·Archives of Orthopaedic and Trauma Surgery·C A CarlstedtT Wredmark
Jan 1, 1987·Archives of Orthopaedic and Trauma Surgery·C A CarlstedtT Wredmark
Jan 1, 1986·Archives of Orthopaedic and Trauma Surgery·L F SolheimN Langeland
Jan 1, 1995·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·M LeunigR K Jain
Dec 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J M WittenbergJ F Osborn
Feb 5, 2003·Injury·Vincenzo GiordanoRenato Das C Gomes
Dec 11, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Stuart GoodmanR Lane Smith
Oct 1, 1995·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·D GiuntaB Melsen
Jun 11, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ann Marie SimonJ Patrick O'Connor
Dec 14, 2007·Journal of Neurosurgery. Spine·Julio UrrutiaFelipe Quezada
Jan 1, 1981·Scandinavian Journal of Rheumatology·R Arumugham, S M Bose
May 25, 2010·Pharmaceuticals·Jessica Cottrell, J Patrick O'Connor
Feb 1, 1988·Acta Orthopaedica Scandinavica·R ShindellJ F Connolly
Jan 1, 1987·Acta Orthopaedica Scandinavica. Supplementum·C A Carlstedt
Jan 26, 1999·Clinical Orthopaedics and Related Research·R A HaydaJ L Esterhai
Dec 1, 1991·Acta Orthopaedica Scandinavica·J M Wittenberg, R H Wittenberg

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