PMID: 893029Jan 1, 1977Paper

Effect of indomethacin on renal function in anaesthetized dogs

International Urology and Nephrology
J Bartha


The inhibitory action of indomethacin administered as a single-dose injection (4mg/kg) was examined under general anaesthesia in dogs, moderate volume expansion having been induced with physiological saline infusion. At 20 to 30 min after the administration of indomethacin, excretion of Na and water showed a fall of the same extent, GFR remaining stable and the effective plasma flow (CPAH) declining. RBF estimated by the 86Rb method decreased from 411 +/- 96 ml/min/100 g to 292 +/- 53 ml/min/100 g (p less than 0.01). This fall was coupled with an intrarenal redistribution of blood flow. While the cortical fraction of renal blood flow increased from 79% to 83.9% (p less than 0.001), its outer medullary fraction decreased from 17% to 13.2% (p less than 0.001) and its inner medullary fraction from 4.0% to 2.8% (p less than 0.05). The renal, primarily the medullary, vasculature is assumed on these grounds to be under the influence of a continuous secretion of prostaglandins which thus seem to be involved in the physiological control of intrarenal distribution of blood flow and of sodium and water excretion.


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Jan 1, 1969·Physiological Reviews·E W Horton
Jul 1, 1973·The American Journal of Physiology·J B Gross, F C Barter
Sep 8, 1970·Biochimica Et Biophysica Acta·D G Ahern, D T Downing
May 1, 1972·The American Journal of Physiology·M Martinez-MaldonadoW N Suki
May 1, 1972·Clinical Science·S G Massry, J J Ahumada
Jun 23, 1971·Nature: New Biology·J B Smith, A L Willis
Feb 1, 1970·The Biochemical Journal·K Crowshaw, J Z Szlyk
Feb 1, 1968·The American Journal of Physiology·A J Vander
Oct 1, 1967·The American Journal of Physiology·L HársingJ Bartha
Oct 1, 1967·The American Journal of Physiology·H H JohnstonD P Lauler
May 1, 1945·The Journal of Clinical Investigation·H W SmithM Graber

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Jan 1, 1977·Pflügers Archiv : European journal of physiology·G Kövér, H Tost

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