Effect of indomethacin on reproduction under laboratory and field conditions in deermice (Peromyscus maniculatus)

Biology of Reproduction
R R Seeley

Abstract

The purpose of this investigation was to determine the long-term effect of enterically administered indomethacin (a prostaglandin synthetase inhibitor) on reproduction in Peromyscus maniculatus (deermice) under both laboratory and field conditions. Indomethacin-coated wheat (1 mg/kg wheat) was provided to the experimental animals in the laboratory and under field conditions ad libitum. Rat chow was also provided to the animals in the laboratory. The laboratory data indicate that the number and size of the litters from the control breeding pairs were larger (number of litters=22; average number of pups/litter=4.9) than the experimental breeding pairs (number of litters=2; average number of pups/litter=2.5) over a 100-day experimental period. Field data indicate that the number of pregnant animals, the total number of animals, and mean juvenile males and females live-trapped decreased in the experimental group with respect to the control group during the experiment. The data suggest that deermice will consume indomethacin under both laboratory and field conditions, and that it effectively inhibits reproduction on a long-term basis. It is, therefore, possible that prostaglandin synthetase inhibitors may be used to control populati...Continue Reading

Citations

Jul 10, 2003·Fertility and Sterility·Ana C MartiniMarta Fiol de Cuneo
Oct 1, 1992·American Journal of Reproductive Immunology : AJRI·A SchoenfeldY Ovadia
Nov 1, 1988·Seminars in Arthritis and Rheumatism·R RoubenoffD B Hellmann
Dec 1, 1985·American Journal of Reproductive Immunology and Microbiology : AJRIM·D A Clark

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