Effect of induced chronic atrial fibrillation on exercise performance in Standardbred trotters

Journal of Veterinary Internal Medicine
Rikke BuhlThomas Jespersen

Abstract

Atrial fibrillation (AF) is the most common arrhythmia affecting performance in horses. However, no previous studies have quantified the performance reduction in horses suffering from AF. To quantify the effect of AF on maximum velocity (Vmax ), maximum heart rate (HRmax ), heart rate recovery (T100 ), hematologic parameters and development of abnormal QRS complexes. Nine Standardbred trotters. Two-arm controlled trial. Six horses had AF induced by means of a pacemaker and 3 served as sham-operated controls. All horses were subjected to an exercise test to fatigue before (SET1) and after (SET2) 2 months of AF or sham. The Vmax and HRmax were assessed using a linear mixed normal model. Abnormal QRS complexes were counted manually on surface ECGs. Atrial fibrillation resulted in a 1.56 m/sec decrease in Vmax (P < .0001). In the AF group, HRmax  ± SD increased from 226 ± 11 bpm at SET1 to 311 ± 27 bpm at SET 2. The AF group had higher HRmax at SET2 compared with controls (P < .0001), whereas no difference between the control and AF groups was observed at SET1 (P = .96). Several episodes of wide complex tachycardia were observed during exercise in 3 of the AF horses during SET2. Atrial fibrillation resulted in a significant reducti...Continue Reading

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Citations

Feb 29, 2020·Journal of Cardiovascular Electrophysiology·Dominik LinzPrashanthan Sanders
Jun 9, 2020·Equine Veterinary Journal·Rikke BuhlStefan Michael Sattler
Jan 21, 2021·The Veterinary Journal·Annelies DecloedtGunther van Loon
Feb 20, 2021·Journal of Veterinary Internal Medicine·Laura C NathSamantha Franklin
Feb 25, 2021·British Journal of Pharmacology·Arnela SaljicRikke Buhl
Sep 27, 2021·Equine Veterinary Journal·Antoine PremontKamalan Jeevaratnam
Dec 17, 2021·Journal of Veterinary Pharmacology and Therapeutics·Daniela LuethyJoann Slack

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GraphPad Prism

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