Abstract
As a promising candidate, biodegradable Poly-L-lactic Acid (PLLA) has been extensively used in coronary artery stents. In our previous reports, PLLA stents implanted in porcine coronary arteries showed safety without stent thrombosis. However, inflammatory responses were observed, which needed further study. In this study, human aortic endothelial cells (HAEC) were treated with different volume percentages of extract of pre-degraded PLLA (extract of PLLA) in vitro, and the cell growth curve and morphological changes were examined. The expression of inflammatory cytokines such as NF-κB, VEGF and VCAM-1 were also observed by ELISA. In addition, PLLA stent was implanted in porcine coronary artery to examine morphological changes, functional marker eNOS and inflammatory responses. The extract of PLLA caused significant growth inhibition and release of NF-κB, VEGF and VCAM-1 in HAEC with volume percentage-dependence. Although re-endothelialization and expression of eNOS was observed, expression of NF-κB and lymphocytes surrounding PLLA were also found after PLLA stents were implanted in the artery. This study demonstrated the effects of inflammation on endothelial cells induced by PLLA degradation in vitro and showed the inflammatio...Continue Reading
References
Jul 25, 2000·Circulation·H TamaiH Uehata
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Apr 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Claudia MonacoMarc Feldmann
Jan 27, 2005·Blood·Markus GubaChristiane J Bruns
Sep 28, 2005·International Journal of Cardiology·Raisuke IijimaKazuhiro Hara
Apr 14, 2007·Biomacromolecules·Pakakrong SangsanohPitt Supaphol
Mar 18, 2008·Lancet·John A OrmistonSusan Veldhof
Apr 29, 2008·Biomaterials·David F Williams
May 26, 2009·JACC. Cardiovascular Interventions·Yaling HanUNKNOWN CREATE (Multi-Center Registry of Excel Biodegradable Polymer Drug-Eluting Stents) Investigators
Apr 13, 2010·Biomaterials·Tingfei XiShengping Zhong
Mar 23, 2011·Biomacromolecules·Enrica SainoLivia Visai
Sep 1, 2012·PloS One·Gayathri AcharyaYugyung Lee
Jan 29, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Piotr P BuszmanPaweł E Buszman
May 9, 2014·Journal of Biomedical Nanotechnology·Zhiyuan LanTim Wu
Sep 19, 2014·Lancet·Patrick W SerruysYoshinobu Onuma
Sep 4, 2015·European Heart Journal·Takeshi KimuraUNKNOWN ABSORB Japan Investigators
Oct 13, 2015·The New England Journal of Medicine·Stephen G EllisUNKNOWN ABSORB III Investigators
Oct 17, 2015·Journal of the American College of Cardiology·Runlin GaoUNKNOWN ABSORB China Investigators
Oct 28, 2015·Journal of Biomedical Nanotechnology·Jianmin XiaoRoger Laham
May 8, 2016·The Annals of Thoracic Surgery·Tadahisa SugiuraToshiharu Shinoka
Apr 13, 2017·The New England Journal of Medicine·Joanna J WykrzykowskaUNKNOWN AIDA Investigators
Citations
May 16, 2019·Cardiovascular and Interventional Radiology·Jung-Hoon ParkKun Yung Kim
May 18, 2020·International Journal of Molecular Sciences·Daniel Wee Yee ToongYingying Huang
Aug 14, 2019·Journal of Biomedical Materials Research. Part a·Dongping ChenJianmin Xiao
Oct 28, 2020·Cardiovascular Engineering and Technology·Dongping ChenJianmin Xiao
Jun 25, 2021·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Jin-Sin KohHabib Samady