PMID: 8441332Jan 1, 1993Paper

Effect of inflammatory cell mediators on M2 muscarinic receptors in the lungs

Life Sciences
A D Fryer, D B Jacoby

Abstract

Acetylcholine released from vagal nerve endings constricts airways by stimulating M3 muscarinic receptors on the airway smooth muscle. At the same time, released acetylcholine feeds back onto inhibitory M2 muscarinic autoreceptors on the nerve endings, limiting further release of acetylcholine. Loss of function of these M2 receptors increases vagally-mediated bronchoconstriction after viral airway infections, exposure to ozone, or antigen inhalation. Viral infections may decrease M2 receptor function by inducing inflammation or via direct damage to the receptors as a result of cleavage of sialic acid residues by viral neuraminidase. Inflammation appears to be critical in the loss of M2 receptor function after ozone exposure. Antigen-induced loss of M2 receptor function can be reversed acutely by administering the poly-anionic substances heparin or poly-l-glutamate, possibly by binding and neutralizing positively charged eosinophil proteins. Such positively charged eosinophil proteins, particularly major basic protein, may be acting as endogenous inhibitors at the M2 receptors, as can be demonstrated in in vitro ligand binding studies.

References


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Citations

Jan 5, 2002·European Journal of Pharmacology·Tomoyuki YahataMitsuhiro Yokoyama
Sep 24, 1998·Trends in Pharmacological Sciences· Haddad el-B, J Rousell
Mar 4, 2000·The Journal of Emergency Medicine·L Rossman
Nov 20, 2001·Current Opinion in Pharmacology·A M LeeA D Fryer
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·Michael P DeLormeDavid J P Bassett
Mar 15, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·A W Bill MuskNicholas H De Klerk
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·N ScichiloneA Togias
May 8, 2015·Lung India : Official Organ of Indian Chest Society·Ritesh AgarwalSubhash Varma
Mar 16, 2007·Pulmonary Pharmacology & Therapeutics·Alberto RicciClaudio Terzano
Mar 11, 2003·Technology in Cancer Research & Treatment·Ruxandra Draghia-AkliPatricia A Brown
Jan 7, 2009·Therapeutic Advances in Respiratory Disease·Michele BaroffioVito Brusasco
Oct 21, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·J K L WalkerJ T Fisher
Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Monika I HollenhorstGabriela Krasteva-Christ
Apr 13, 1999·The American Journal of Physiology·J K WalkerJ T Fisher

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