Effect of influenza vaccinations on immune response and serum eotaxin level in patients with allergic bronchial asthma

Mediators of Inflammation
K Jahnz-RózykT Plusa

Abstract

One of the most promising markers of allergic inflammation is eotaxin, which has a selective influence on the migration of eosinophils. Its serum content significantly correlates with the intensity of allergic symptoms, so it might be interesting to know whether vaccination has any influence on serum expression of this chemokine. Comparison of the humoral response to influenza vaccine and post-vaccination changes in the serum eotaxin level in patients with allergic bronchial asthma and healthy controls. Forty-two asthmatics and 45 healthy individuals were vaccinated with a single dose of influenza subunit vaccine (Influvac). The serum eotaxin level and the antibody response to haemagglutinin (HI) and neuraminidase (NI) glycoproteins were measured before and after vaccination. A significant increase of geometric mean titres of HI and NI was observed in both groups. There were no significant differences between the groups in meanfold increase of HI and NI titres, response rate and protective level of HI. After vaccination, a significant decrease of the mean serum eotaxin value was observed in patients with asthma (149.4 +/- 71.0 versus 125.1 +/- 67.0, p= 0.0017), while no similar effect was present in healthy individuals (153.4 +...Continue Reading

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Citations

May 7, 2014·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Dandan WuXin Yao
Feb 20, 2013·Respiratory Physiology & Neurobiology·L B BrydakA Nitsch-Osuch
Feb 14, 2007·European Journal of Epidemiology·C LocquetG Vidal-Trecan

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