PMID: 234693Mar 1, 1975

Effect of infusion of pharmacologic amounts of vasopressin on renal electrolyte excretion

The American Journal of Physiology
N A KurtzmanJ A Arruda

Abstract

Aqueous vasopressin was infused to bicarbonate- and glucose-loaded dogs and to nonloaded antidiuretic dogs in doses of 50 mU/kg per min or 50 mU/kg per h. Both doses caused a marked increase in sodium, chloride, and water excretion. The larger dose raised the fractional excretion (sodium clearance (C-Na)/glomerular filtration rate (GFR) times 100) of these ions from 2% or less to in excess of 20%. Blocking the pressor effects of these doses of vasopressin with sodium nitroprusside did not alter the marked natriuretic and chloriuretic effect. The maximal rate of bicarbonate and glucose reabsorption was not depressed by vasopressin infusion; fractional phosphate excretion, however, was markedly increased. Inhibiting distal hydrogen ion secretion by inducing selective aldosterone deficiency failed to uncover a vasopressin-induced inhibition of proximal bicarbonate reabsorption that might have been masked by increased distal bicarbonate reabsorption. There was no significant change in GFR, renal plasma flow, or filtration fraction. The distribution of cortical renal blood flow (measured by the radioactive microsphere technique) shifted toward the inner cortex after vasopressin administration. Vasopressin, in pharmacologic doses, is...Continue Reading

Citations

Jan 1, 1984·Scandinavian Journal of Plastic and Reconstructive Surgery·E VernerssonM Aberg
Oct 2, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Hitoshi IkegamiMasato Nishihara
Oct 1, 1979·Postgraduate Medical Journal·P L Padfield, J J Morton
Jan 1, 1982·Annals of the New York Academy of Sciences·S Opava-StitzerP Stern
Jun 25, 1998·The American Journal of Physiology·E Kompanowska-JezierskaP Bie
Apr 1, 1995·Cardiovascular Drugs and Therapy·R Babini, P du Souich
Jan 1, 1983·Scandinavian Journal of Plastic and Reconstructive Surgery·E VernerssonK F Aronsen
Aug 25, 1978·Pflügers Archiv : European journal of physiology·G Fejes-TothJ Walter
Sep 29, 2004·Acta Physiologica Scandinavica·A B RoaldK Aukland
Oct 22, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Adel MohamedPatrick J McNamara

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