Effect of inhalation aspirin challenge on exhaled nitric oxide in patients with aspirin-inducible asthma

Allergy
Giovanni RollaCaterina Bucca

Abstract

A complex relationship between arachidonic acid metabolites and nitric oxide (NO) synthesis has been reported in asthma. The effects of inhaled aspirin on fractional exhaled NO (FENO) in patients with aspirin-tolerant (ATA) and aspirin-inducible (AIA) asthma compared with normal controls have been investigated. The FENO was measured baseline, after saline and lysine-aspirin (L-ASA) bronchial challenge in 10 patients with ATA and in 10 patients with AIA [mean (PD(20)FEV(1) L-ASA): 14.7 +/- 12.7 mg], who had comparable age and baseline FEV(1). Ten healthy subjects served as controls. Sputum eosinophils were counted after saline and after L-ASA challenge in the two groups of asthmatics. Asthmatic patients had baseline FENO significantly higher than controls (29.7 +/- 6.8 vs 9.8 +/- 2.05 p.p.b. respectively, P < 0.0001). No difference was observed in methacholine PD(20)FEV(1) and baseline FENO between ATA and AIA patients. After L-ASA inhalation, FENO increased significantly only in patients with AIA, reaching the peak value 4 h after bronchoconstriction (from 31.1 +/- 6 to 43 +/- 4.8 p.p.b., P < 0.001), while no change was observed in patients with ATA and in controls. Sputum eosinophils increased significantly after L-ASA inhalat...Continue Reading

References

Oct 1, 1975·The Journal of Allergy and Clinical Immunology·H ChaiR G Townley
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·A R AminS B Abramson
Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·S A KharitonovP J Barnes
Jan 15, 1994·Lancet·S A KharitonovP J Barnes
May 1, 1993·The American Review of Respiratory Disease·J V FahyH A Boushey
Jan 1, 1996·Proceedings of the Society for Experimental Biology and Medicine·M L McDanielJ A Corbett
Dec 1, 1996·American Journal of Respiratory and Critical Care Medicine·A SzczeklikJ Oates
Jul 9, 1998·American Journal of Respiratory and Critical Care Medicine·H W de GouwP J Sterk
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·S A KharitonovK F Chung
Jul 10, 1999·The Journal of Allergy and Clinical Immunology·A Szczeklik, D D Stevenson
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·H BisgaardJ A Oj
Dec 22, 1999·The European Respiratory Journal·S A KharitonovP J Barnes
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·A JatakanonP J Barnes
Mar 17, 2000·Science·T MatsuokaS Narumiya
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·A DeykinE Israel
Jun 9, 2001·Antioxidants & Redox Signaling·D Pérez-Sala, S Lamas
Dec 12, 2001·American Journal of Respiratory and Critical Care Medicine·L M van den ToornJ B Prins

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

American Journal of Respiratory Cell and Molecular Biology
I OhnoK Shirato
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
M Pilar Berges-GimenoDonald D Stevenson
© 2022 Meta ULC. All rights reserved