Abstract
A complex relationship between arachidonic acid metabolites and nitric oxide (NO) synthesis has been reported in asthma. The effects of inhaled aspirin on fractional exhaled NO (FENO) in patients with aspirin-tolerant (ATA) and aspirin-inducible (AIA) asthma compared with normal controls have been investigated. The FENO was measured baseline, after saline and lysine-aspirin (L-ASA) bronchial challenge in 10 patients with ATA and in 10 patients with AIA [mean (PD(20)FEV(1) L-ASA): 14.7 +/- 12.7 mg], who had comparable age and baseline FEV(1). Ten healthy subjects served as controls. Sputum eosinophils were counted after saline and after L-ASA challenge in the two groups of asthmatics. Asthmatic patients had baseline FENO significantly higher than controls (29.7 +/- 6.8 vs 9.8 +/- 2.05 p.p.b. respectively, P < 0.0001). No difference was observed in methacholine PD(20)FEV(1) and baseline FENO between ATA and AIA patients. After L-ASA inhalation, FENO increased significantly only in patients with AIA, reaching the peak value 4 h after bronchoconstriction (from 31.1 +/- 6 to 43 +/- 4.8 p.p.b., P < 0.001), while no change was observed in patients with ATA and in controls. Sputum eosinophils increased significantly after L-ASA inhalat...Continue Reading
References
Oct 1, 1975·The Journal of Allergy and Clinical Immunology·H ChaiR G Townley
Jul 1, 1990·The American Review of Respiratory Disease·M C LiuW C Hubbard
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·A R AminS B Abramson
Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·S A KharitonovP J Barnes
Oct 1, 1994·The European Respiratory Journal·P SestiniS Bianco
Jan 15, 1994·Lancet·S A KharitonovP J Barnes
May 1, 1993·The American Review of Respiratory Disease·J V FahyH A Boushey
Jan 1, 1996·Proceedings of the Society for Experimental Biology and Medicine·M L McDanielJ A Corbett
Dec 1, 1996·American Journal of Respiratory and Critical Care Medicine·A SzczeklikJ Oates
Jun 13, 1998·Thorax·A JatakanonP J Barnes
Jul 9, 1998·American Journal of Respiratory and Critical Care Medicine·H W de GouwP J Sterk
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·S A KharitonovK F Chung
Jul 10, 1999·The Journal of Allergy and Clinical Immunology·A Szczeklik, D D Stevenson
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·H BisgaardJ A Oj
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine
Dec 22, 1999·The European Respiratory Journal·S A KharitonovP J Barnes
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·A JatakanonP J Barnes
Feb 19, 2000·Thorax·S LimP J Barnes
Mar 17, 2000·Science·T MatsuokaS Narumiya
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·A DeykinE Israel
Jun 9, 2001·Antioxidants & Redox Signaling·D Pérez-Sala, S Lamas
Sep 12, 2001·Allergy·G MelilloS Suetsugu
Dec 12, 2001·American Journal of Respiratory and Critical Care Medicine·L M van den ToornJ B Prins
Citations
Oct 26, 2012·International Archives of Allergy and Immunology·R Muñoz-CanoA Valero
Sep 6, 2005·Environmental Health Perspectives·Hanns Moshammer
Apr 9, 2005·Allergy·M L KowalskiR Pawliczak
Aug 4, 2005·Allergy·M L KowalskiL Dubuske
Sep 23, 2016·Current Opinion in Pulmonary Medicine·Duy Le PhamHae-Sim Park
Oct 12, 2012·American Journal of Rhinology & Allergy·Damian TworekPiotr Kuna