Effect of Inhalation Flow Rate on Mass-Based Plume Geometry of Commercially Available Suspension pMDIs

The AAPS Journal
Daniel Moraga-EspinozaHugh D C Smyth

Abstract

Although high-speed laser imaging is the current standard to characterize the plume angle of suspension-based pressurized metered dose inhalers (pMDIs), this method is limited by the inability to identify the drug content in a droplet and simulate inhalation flow. The Plume Induction Port Evaluator (PIPE) is a modified induction port for cascade impactors that allows for the calculation of the angle of a plume based on direct drug mass quantification rather than indirect droplet illumination under airflow conditions. The objective of this study was to investigate the use of the PIPE apparatus to evaluate the effect of airflow on the Mass Median Plume Angle (MMPA) of commercially available suspension-based pMDIs (Ventolin® HFA, ProAir® HFA, and Proventil® HFA). Deposition patterns within PIPE were log-normally distributed allowing for the calculation of the MMPA for the three suspension products. Mass-based plume angles were significantly smaller (narrower angle) when inhalation airflow was used compared to no flow conditions (reduction of MMPA was 8, 16, and 13% for Ventolin® HFA, ProAir® HFA, and Proventil® HFA, respectively). Additionally, new parameters for characterizing plume geometry were calculated (MMPA ex-actuator and ...Continue Reading

References

Sep 2, 1999·International Journal of Pharmaceutics·B J GabrioD J Velasquez
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Oct 30, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Y S ChengY Zhou
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Apr 24, 2008·AAPS PharmSciTech·Matthew BonamBruce Wyka
Nov 3, 2011·International Journal of Pharmaceutics·Stephen W SteinPaul B Myrdal
Dec 21, 2011·International Journal of Pharmaceutics·Xiaofei LiuChangning Guo
Dec 24, 2011·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Jacquelyn Cruz McCabeXian-Ming Zeng
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Oct 3, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Renish R DelvadiaPeter R Byron
Aug 6, 2013·International Journal of Pharmaceutics·Poonam ShethPaul B Myrdal
Sep 18, 2014·Journal of Pharmaceutical Sciences·William H DoubDiem Ngo
Apr 11, 2018·International Journal of Pharmaceutics·Daniel Moraga-EspinozaHugh D C Smyth

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