Effect of inhaled bronchodilators on air trapping in patients with stable asthma

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Ryoji ItoJitsuo Higaki

Abstract

Air trapping is frequently observed during high-resolution computed tomography (HRCT) of patients with asthma, but whether the condition is reversible has not been thoroughly investigated. The aim of the present study was to evaluate reversibility of air trapping in response to bronchodilator. Ten never-smokers with stable asthma enrolled in the study. Spirometry and HRCT were performed before and after bronchodilator inhalation. Air trapping remained unchanged, although significant reversibility of FEV(1) was observed. Air trapping scores correlated significantly with airway wall thickness. These observations suggest that air trapping is irreversible and that it represents structural remodeling of small airways in patients with stable asthma.

References

Jan 1, 1984·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·M MitsuhashiT Kuroume
May 1, 1995·American Journal of Respiratory and Critical Care Medicine·A YokoyamaK Hiwada
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·F PaganinJ Bousquet
Mar 1, 1996·AJR. American Journal of Roentgenology·N A Obuchowski, R C Zepp
Apr 1, 1996·The European Respiratory Journal·N CarrollA James
Nov 1, 1996·American Journal of Respiratory and Critical Care Medicine·M KraftR J Martin
Jul 1, 1997·The Journal of Allergy and Clinical Immunology·Q HamidJ C Hogg
Jan 13, 1998·The European Respiratory Journal·W BiernackiW MacNee
Feb 11, 1998·AJR. American Journal of Roentgenology·O LucidarmeP Grenier
Mar 2, 1999·American Journal of Respiratory and Critical Care Medicine·G G KingP D Paré
Mar 21, 2000·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·T A MitchellJ D Newell
Sep 21, 2000·European Radiology·F LaurentJ M Tunon-de-Lara
Oct 13, 2000·American Journal of Respiratory and Critical Care Medicine·A NiimiT Izumi
Aug 9, 2001·The European Respiratory Journal·D M Hansell
Feb 14, 2002·The Journal of Allergy and Clinical Immunology·Richard J Martin
Apr 27, 2002·European Radiology·Philippe A GrenierStéphane Lenoir
Sep 6, 2002·The European Respiratory Journal·S BalzarH W Chu
Dec 19, 2003·The European Respiratory Journal·H GonoK Kubo

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Citations

Jan 9, 2019·European Radiology·Xiaoxian ZhangNanshan Zhong
Sep 29, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·James H HolmesSean B Fain
Sep 8, 2006·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Hironobu Hamada, Akihito Yokoyama

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