Effect of Inhaled Cannabis for Pain in Adults With Sickle Cell Disease: A Randomized Clinical Trial

JAMA Network Open
D I AbramsKalpna Gupta

Abstract

Sickle cell disease (SCD) is characterized by chronic pain and episodic acute pain caused by vasoocclusive crises, often requiring high doses of opioids for prolonged periods. In humanized mouse models of SCD, a synthetic cannabinoid has been found to attenuate both chronic and acute hyperalgesia. The effect of cannabis on chronic pain in adults with SCD is unknown. To determine whether inhaled cannabis is more effective than inhaled placebo in relieving chronic pain in adults with SCD. This pilot randomized clinical trial included participants with SCD with chronic pain admitted to a single inpatient clinical research center for 2 separate 5-day stays from August 2014 to April 2017. Participants inhaled either vaporized cannabis (4.4% Δ-9-tetrahydrocannabinol to 4.9% cannabidiol) 3 times daily or vaporized placebo cannabis. Pain and pain interference ratings using the Brief Pain Inventory were assessed throughout each 5-day period. Participants with SCD and chronic pain on stable analgesics were eligible to enroll. A total of 90 participants were assessed for eligibility; 56 participants were deemed ineligible, and 34 participants were enrolled. Of these, 7 participants dropped out before randomization. Of 27 randomized partic...Continue Reading

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Citations

Sep 26, 2020·The Cochrane Database of Systematic Reviews·Oluseyi Oniyangi, Damian H Cohall
Jan 28, 2021·Journal of Clinical Medicine·Samir K Ballas
Dec 5, 2020·Journal of Clinical Medicine·Donovan A ArguetaKalpna Gupta
Mar 13, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Varun SagiKalpna Gupta
Apr 20, 2021·Disability and Health Journal·Rachel BartlettMonika Asnani
May 9, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Akeemat O TijaniAshana Puri
Aug 27, 2021·Nature·Bianca Nogrady

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BETA
pregnancy test
sedation

Software Mentioned

SAS

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