Effect of inhaled disodium cromoglycate and albuterol on energy cost of running in asthmatic children

Pediatric Pulmonology
S ZanconatoF Zacchello

Abstract

The purpose of this study is to evaluate the effect of disodium cromoglycate and albuterol on energy cost of running, gas exchange, and ventilation during maximal exercise in children with exercise-induced asthma (EIA). Twelve children (7.1-15.5 years old) with a history of mild to moderate asthma and EIA performed three maximal exercise tests on a treadmill: 1) test A, without premedication; 2) test B, after premedication with inhaled disodium cromoglycate (DSCG) (40 mg); 3) test C, after premedication with inhaled albuterol (200 micrograms). The energy cost of running was calculated at each minute of exercise. None of the children were limited by dyspnea during the run. The post-exercise fall in FEVi after test A was greater than 20% for each child, the mean fall being 32.8 +/- 11.6%, in comparison with 12.6 +/- 8.9% after test B (P less than 0.001) and 2.5 +/- 5.3% after test C (P less than 0.001). There was no difference in the baseline oxygen uptake for the three tests. Maximum oxygen uptake (VO2 peak) decreased from 43.9 +/- 7.7 mL/min/kg in test A to 37.7 +/- 6.0 mL/min/kg in test B (P less than 0.01) and 39.1 +/- 7.2 mL/min/kg in test C (P less than 0.05). Ventilatory anaerobic threshold in tests B and C was significant...Continue Reading

References

Jun 1, 1979·Thorax·K A Feisal, F J Fuleihan
Dec 1, 1975·Australian and New Zealand Journal of Medicine·S D AndersonD A Lindsay
Apr 1, 1986·International Journal of Sports Medicine·P E di Prampero
Jun 1, 1986·Medicine and Science in Sports and Exercise·P A Eggleston
Jan 1, 1985·European Journal of Applied Physiology and Occupational Physiology·P J NearyH A Wenger
Jan 1, 1971·Acta Paediatrica Scandinavica. Supplement·J VavraV Spicak
Nov 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·V J CaiozzoW C McMaster

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Citations

Jul 1, 1992·Pediatric Pulmonology·E BaraldiF Zacchello
Jun 1, 1994·Pediatric Pulmonology·V B UnnithanJ Y Paton
Sep 26, 2002·Paediatric Respiratory Reviews·Kai-Håkon Carlsen, Karin C L Carlsen
Jan 27, 1999·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·K H Carlsen
Oct 30, 2003·The Cochrane Database of Systematic Reviews·C H SpoonerB H Rowe
Jun 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K H Carlsen, K Larsson
Apr 1, 1997·Medicine and Science in Sports and Exercise·F P CounilC Préfaut
Oct 4, 2013·The Cochrane Database of Systematic Reviews·Matteo BoniniGiorgio W Canonica

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