Effect of inhaled steroids on lung function in young children: a cohort study

The European Respiratory Journal
C S DevulapalliKarin C Lødrup Carlsen

Abstract

The objectives of the present study were to determine the use of inhaled corticosteroids (ICS) for treating recurrent bronchial obstruction (rBO) in young children up to 2 yrs of age and to assess possible modifying effects of ICS on lung function in young children with rBO. From an observational, noninterventional birth cohort of 3,754 newborn children (3,697 with complete questionnaire data by 2 yrs of age), 306 children with documented rBO by age 2 yrs (cases) were identified along with 306 matched controls. Two tidal flow/volume measurements were taken, one at presentation of disease (children were steroid naive) and one at 2 yrs of age (mean age 11.2 and 25.6 months, respectively), from: 21 cases who subsequently received ICS (ICS+); 33 who did not (ICS-); and in 15 controls. The mean +/- SD duration of ICS treatment was 10.3 +/- 6.5 months. The main outcomes were treatment with ICS and baseline ratio of time to peak expiratory flow/total expiratory time (tPTEF/tE). From the entire cohort, 77 children (2.1%) and 21% of children with rBO had received ICS by 2 yrs of age. Baseline tPTEF/tE was significantly lower at the first visit only in ICS+ as compared to ICS- subjects, as well as in ICS+ and ICS- as compared to controls...Continue Reading

Citations

Dec 14, 2004·American Journal of Respiratory and Critical Care Medicine·Alejandro M TeperAlberto F Maffey
Nov 17, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Karin C Lødrup CarlsenKai-Håkon Carlsen
Aug 17, 2005·Infectious Disease Clinics of North America·Tuomas JarttiOlli Ruuskanen
May 22, 2007·Respiratory Medicine·Chandra Sekhar DevulapalliKai-Håkon Carlsen
May 4, 2006·Current Opinion in Allergy and Clinical Immunology·Alejandro Manuel Teper, Carlos Daniel Kofman
Mar 5, 2008·Current Opinion in Allergy and Clinical Immunology·Kai-Håkon Carlsen, Karin C L Carlsen
Dec 16, 2006·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Lise Reindal, Knut Øymar

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