PMID: 6402626Mar 7, 1983Paper

Effect of inhibin-like activity on LH-RH-stimulated release of FSH by pituitary glands from female rats in vitro

Life Sciences
A A JennerG P van Rees

Abstract

During long-term incubation of pituitary glands from intact female rats in the presence of inhibin-like activity, LH-RH-stimulated release of FSH becomes inhibited after 4 h of incubation. However, at the same time inhibition of basal FSH release is included. Therefore, glands were at first incubated for 4 h in the presence of inhibin-like activity to block basal release completely and thereafter LH-RH was added to the medium. It was found that LH-RH still could stimulate FSH release, despite the continuous presence of inhibin-like activity. This means that LH-RH-stimulated release of FSH could be investigated separately from basal release. Using this way of incubation, it was found that part of the action of LH-RH on FSH release was independent of protein synthesis. Also part of LH-RH-stimulated FSH release was independent of the presence of extracellular Ca2+. Furthermore it was found that LH-RH, when added after 4 h of incubation did stimulate FSH synthesis, in the presence as well as absence of inhibin-like activity. The present results indicate that LH-RH-stimulated release of FSH is not affected by inhibin-like activity. Complete inhibition of basal release and synthesis of FSH does not prevent LH-RH from stimulating FSH ...Continue Reading

References

Jan 1, 1979·Vitamins and Hormones·P FranchimontJ Hustin
Jan 1, 1979·The Journal of Endocrinology·F H de JongH J van der Molen
Jan 1, 1979·Molecular and Cellular Endocrinology·F H de Jong
Jun 1, 1976·Molecular and Cellular Endocrinology·J de KoningG P van Rees
Jan 1, 1981·Journal of Medical Virology·J HeritageD J McCance
Dec 1, 1981·Acta Endocrinologica·K RamasharmaM R Ranganathan
Aug 1, 1982·Acta Endocrinologica·A A JennerG P van Rees

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Citations

Jun 23, 2005·Reproductive Biomedicine Online·Philip KumanovAshok Agarwal
Sep 1, 1988·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·S R DavisH G Burger
Sep 1, 1992·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·F J BroekmansJ Schoemaker
Jul 1, 1988·Clinical Endocrinology·R I McLachlanH G Burger

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