Effect of inhibiting the lactogenic signal at calving on milk production and metabolic and immune perturbations in dairy cows

Journal of Dairy Science
N VanackerP Lacasse

Abstract

During the periparturient period, the abrupt increase in energy demand for milk production often induces metabolic and immunological disturbances in dairy cows. Our previous work has shown that reducing milk output by milking once a day or incompletely in the first few days of lactation reduces these disturbances. The aim of this study was to reduce metabolic and immunological disturbances by limiting milk production during the first week of lactation by inhibiting the lactogenic signal driven by prolactin. Twenty-two fresh cows received 8 i.m. injections of the prolactin-release inhibitor quinagolide (QUIN; 2 mg) or water as a control (CTL). The first injection was given just after calving, and the subsequent 7 injections were given every 12 h. Milk production was measured until d 28 after calving. Blood samples were taken from d 1 (calving) to d 5 and then on d 7, 10, 14, 21, and 28 to measure concentrations of urea, phosphorus, calcium, glucose, nonesterified fatty acids (NEFA), β-hydroxybutyrate, and prolactin. Other blood samples were taken on d 2, 5, 10, and 28 to analyze oxidative burst, phagocytosis, and the effect of the serum on the lymphoproliferation of peripheral blood mononuclear cells from donor cows. Blood prola...Continue Reading

References

Feb 1, 1978·Endocrinologia Japonica·T Johke, K Hodate
Oct 1, 1987·Domestic Animal Endocrinology·K PlautR M Akers
May 22, 2004·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·J B AndersenK L Ingvartsen
May 21, 2005·Journal of Dairy Science·N LaceteraA Nardone
Mar 16, 2006·Journal of Dairy Science·S J LeBlancK E Leslie
Jun 3, 2006·Veterinary Immunology and Immunopathology·D S HammonJ L Walters
Feb 23, 2011·Journal of Dairy Science·P LacasseM Boutinaud
Mar 1, 2012·Journal of Dairy Science·K O'DriscollL Boyle
Mar 8, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicola RomanòAgnès O Martin
Jun 24, 2015·The Journal of Endocrinology·David R Grattan

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Citations

Jul 10, 2019·Animal : an International Journal of Animal Bioscience·P LacasseM Boutinaud

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