Effect of inhibition of multiple steps of angiogenesis in syngeneic murine pleural mesothelioma

The Annals of Thoracic Surgery
Robert E MerrittRobert J Korst

Abstract

Angiogenesis is a multistep process in which the endothelial cell plays a pivotal role. We hypothesized that the combination of two antiangiogenic agents with distinct mechanisms of action would more effectively inhibit tumor growth than either agent alone in a murine mesothelioma model. A syngeneic murine mesothelioma flank tumor model (AB-12) was established in BALB/c mice. Separate adenovirus vectors expressing the cDNAs for human pigment epithelium-derived factor (AdPEDF) and a soluble form of the human vascular endothelial growth factor receptor-1 (Adsflt-1) were administered intratumorally. End points measured included tumor size, animal survival, and microvessel density using CD31 immunohistochemistry. An orthotopic model of mesothelioma was established by implanting AB-12 cells into the murine pleural cavity. Simultaneously, AdPEDF and Adsflt-1 were instilled intrapleurally and tumor burden and survival were recorded. The development of pulmonary emphysema was also assessed by calculating the mean linear intercept (a measure of interalveolar septal distance) in histologic lung sections from tumor-free mice after vector administration. In the flank tumor model, the combination of AdPEDF and Adsflt-1 inhibited tumor growt...Continue Reading

References

Dec 2, 1992·International Journal of Cancer. Journal International Du Cancer·M R DavisB W Robinson
Jun 1, 1997·The Journal of Pathology·S Kumar-SinghE Van Marck
Dec 6, 2000·The Journal of Clinical Investigation·Y KasaharaN F Voelkel
Jul 11, 2001·Immunologic Research·J E Ohm, D P Carbone
Jul 27, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P B VermeulenL Y Dirix
Mar 12, 2003·Trends in Biotechnology·Kenneth Lundstrom
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Jun 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jianzhong HuangJessica J Kandel
Jul 2, 2003·Gene Therapy·J A St George
Aug 2, 2003·Nature Reviews. Neuroscience·Joyce Tombran-Tink, Colin J Barnstable

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Citations

Nov 16, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·N I Fernandez-GarciaB Jimenez
Jan 28, 2006·Cancer Gene Therapy·R G van der MostD J Nelson
Oct 14, 2005·The New England Journal of Medicine·Bruce W S Robinson, Richard A Lake
Jan 15, 2014·Survey of Ophthalmology·Anton M Kolomeyer, Marco A Zarbin
Dec 6, 2005·Hematology/oncology Clinics of North America·Jonathan E Dowell, Hedy Lee Kindler
Sep 23, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Paolo A Zucali, Giuseppe Giaccone
Dec 27, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Thierry JahanHedy Lee Kindler
Dec 9, 2016·Human Gene Therapy·Dolan SondhiRonald G Crystal
Aug 8, 2006·Molecular Cancer Therapeutics·Eugene T H EkPeter F M Choong
Jan 1, 2021·Expert Opinion on Drug Discovery·Kenneth P SeastedtChuong D Hoang
Feb 16, 2021·Phytotherapy Research : PTR·Gönül Ulus

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