PMID: 9554252Apr 29, 1998Paper

Effect of inhibitors of enzymes involved in polyamine biosynthesis pathway on pregnancy in mouse and hamster

Contraception
P K MehrotraS Farheen

Abstract

The syntheses of polyamines, which play a definitive role in cell proliferation and tissue growth during early embryogenesis, are believed to be principally regulated by two enzymes: ornithine decarboxylase (ODC) and polyamine oxidase (PAO). However, when the level of enzyme ODC goes down, another enzyme known as S-adenosyl methyl decarboxylase (SAMDC) is believed to up-regulate the biosynthetic pathway. In the present study, the effects of inhibitors of enzymes SAMDC and PAO were determined in mated hamster and mouse in peri-and immediate postimplantation stages of pregnancy. It was noticed that, whereas the SAMDC inhibitor (MDL-73815) failed to arrest the pregnancy in the hamster in spite of raising the dose to 100 mg/kg, the PAO inhibitor (MDL-72527DA) was found to be 100% effective at 75 mg/kg in both species. The results confirmed the role of enzyme PAO in promoting early development of the embryo.

References

Aug 24, 1978·Nature·E O Rijke, R E Ballieux
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Citations

Nov 27, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Diana TetiHarold McNair
Aug 7, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·V L Raghavendra RaoR J Dempsey
Sep 17, 2014·Molecular and Cellular Endocrinology·Fuller W BazerXiaoqiu Wang
Jan 6, 2015·Amino Acids·Fuller W BazerGuoyao Wu
Jul 28, 2011·Endocrine Reviews·Pavine L C LefèvreBruce D Murphy
Nov 13, 2018·Reproduction, Fertility, and Development·Jane C Fenelon, Bruce D Murphy
Feb 24, 2020·Theriogenology·Fuller W BazerGregory A Johnson

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