PMID: 6401669Jan 1, 1983Paper

Effect of inhibitors of prostaglandin synthesis on induced diuresis in cirrhosis

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
D MirouzeT B Reynolds

Abstract

The effect of inhibitors of prostaglandin synthesis on diuretic action was examined in patients with ascites due to chronic liver disease and in normal subjects. In patients with ascites, natriuresis after 80 mg i.v. furosemide was reduced 82% by pretreatment with indomethacin. Creatinine clearance was reduced only 16%. These effects were likely due to inhibition of renal prostaglandin synthesis, since urinary prostaglandin E2 fell and there was also reduction in natriuresis with naproxen (52%). The effects were not specific for furosemide since spironolactone-induced natriuresis was also reduced by indomethacin (82%), naproxen (52%), and aspirin (33%). In normal subjects, indomethacin reduced furosemide natriuresis by only 14% while creatinine clearance was not affected. The mechanisms of these drug interactions are uncertain but probably involve renal hemodynamics which appear to be supported importantly by renal prostaglandins in patients with ascites due to liver disease.

References

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Citations

Jun 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J Reichen
Nov 7, 2001·Current Treatment Options in Gastroenterology·Nelson Garcia, Arun J. Sanyal
May 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S D Levine
Jul 21, 2010·Pharmaceuticals·Walter H Hörl
Nov 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Epstein, M Lifschitz
Mar 17, 2007·Current Hypertension Reports·Hari Krishnan Parthasarathy, Thomas M MacDonald
May 21, 2009·The American Journal of Gastroenterology·Guadalupe Garcia-TsaoUNKNOWN Members of Veterans Affairs Hepatitis C Resource Center Program
Nov 1, 2001·The Cochrane Database of Systematic Reviews·L P Brion, D E Campbell
Oct 13, 2010·Alimentary Pharmacology & Therapeutics·V L MisraN Chalasani
Feb 22, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Joan ClàriaVicente Arroyo
Nov 25, 2003·Prostaglandins & Other Lipid Mediators·Joan Clària, Vicente Arroyo
Mar 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C Guarner, G Soriano
Sep 22, 2001·Clinics in Liver Disease·S Wongcharatrawee, G Garcia-Tsao
Apr 28, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sakib K KhalidGuadalupe Garcia-Tsao

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