PMID: 6168299Jul 17, 1981Paper

Effect of inhibitors of protein synthesis on rat liver spermidine N-acetyltransferase

Biochimica Et Biophysica Acta
I Matsui, Anthony E Pegg

Abstract

The increase in spermidine N-acetyltransferase activity in rat liver produced by carbon tetrachloride was completely prevented by simultaneous treatment with inhibitors of protein and nucleic acid synthesis suggesting that the increase results from the synthesis of new protein rather than the release of the enzyme from a cryptic inactive form. Treatment with cycloheximide 2 h after carbon tetrachloride also completely blocked the rise in spermidine N-acetyltransferase seen 4 h later. Such treatment completely prevented the fall in spermidine and rise in putrescine in the liver 6 h after carbon tetrachloride confirming the importance of the induction of spermidine N-acetyltransferase in the conversion of spermidine into putrescine. When cycloheximide was administered to rats in which spermidine N-acetyltransferase activity had been stimulated by prior treatment with carbon tetrachloride or thioacetamide, the activity was lost rapidly showing that the enzyme protein has a rapid rate of turnover. The half-life for the enzyme in thioacetamide-treated rats was 40 min, whereas the half-life for ornithine decarboxylase (which is well known to turn over very rapidly) was 27 min. In carbon tetrachloride-treated rats the rate or protein ...Continue Reading

References

Jun 6, 1979·Biochimica Et Biophysica Acta·A E Pegg, S McGill
Jun 9, 1978·Biochimica Et Biophysica Acta·H PösöJ Jänne
Jan 1, 1970·Annual Review of Biochemistry·R T Schimke, D Doyle
Sep 5, 1973·Biochemical and Biophysical Research Communications·E HölttäJ Jänne
Jan 1, 1981·The International Journal of Biochemistry·F N Bolkenius, N Seiler
Feb 12, 1980·Biochemical and Biophysical Research Communications·I Matsui, A E Pegg
Oct 1, 1980·Biochimica Et Biophysica Acta·N SeilerP Mamont
Dec 1, 1980·Biochimica Et Biophysica Acta·N SeilerB Knödgen

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Citations

Jan 1, 1989·Chemico-biological Interactions·S NumazawaY Kuroiwa
Feb 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G MarvertiM S Moruzzi
Jan 1, 1983·Critical Reviews in Clinical Laboratory Sciences·D H Russell
Jun 30, 1982·Biochemical and Biophysical Research Communications·I MatsuiA E Pegg
Mar 20, 2008·American Journal of Physiology. Endocrinology and Metabolism·Anthony E Pegg
Oct 9, 2007·Cell Biology International·C Martina HolstStina M Oredsson
Nov 24, 1982·Biochimica Et Biophysica Acta·I MatsuiA E Pegg
Dec 8, 1989·Biochimica Et Biophysica Acta·S MaekawaK Nakashima
Sep 1, 1982·Archives of Biochemistry and Biophysics·H Pösö, A E Pegg

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