Effect of inoculum on the size and location of Fasciola hepatica subsequently recovered from the livers of rats

Veterinary Parasitology
J J ReddingtonR B Wescott

Abstract

Two outbred strains of Sprague-Dawley rats were given, by intraperitoneal injection, 5, 10, 20, 30 or 50 newly excysted juvenile (NEJ) Fasciola hepatica. Ninety days post-infection all rats were killed and their livers teased apart under 10 X magnification for quantitation of the flukes present. There was no significant difference in worm numbers between the rat strains. However, several significant differences (P less than 0.05) between the various infection groups were observed. As the size of the infective dose was increased from 5 to 50 NEJ, the percentage of the infective dose recovered from the livers of the infected rats decreased from 36.7 to 12.1%. With the 5 and 10 NEJ infective doses, the worms recovered were large mature flukes (1.52 and 1.68 cm, respectively) and were found in the common bile ducts. In the rats receiving infections of 30 and 50 NEJ, the flukes were smaller (0.88 and 0.55 cm, respectively), immature, and were primarily located in the liver parenchyma. These findings are important in light of previous studies on the development of resistance in the rat to challenge infections in which immunity was based on both the size and the location of the flukes recovered. The results from our study indicate tha...Continue Reading

References

Jan 1, 1977·Journal of Helminthology·G R Rajasekariah, M J Howell
Apr 1, 1978·Experimental Parasitology·G R Rajasekariah, M J Howell
Aug 1, 1982·International Journal for Parasitology·T G Doy, D L Hughes
Feb 1, 1982·International Journal for Parasitology·C B Chapman, G F Mitchell

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Citations

Jan 1, 1985·Veterinary Parasitology·T R FryR W Leid
Jan 1, 1986·Veterinary Parasitology·J J ReddingtonR B Wescott
Aug 6, 1998·Journal of Immunological Methods·F J van MilligenB A Bokhout

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